한빛사논문
- 조회245
Bang, Ji-In MD, PhD∗; Lee, Won Woo MD, PhD†,‡,§; Cho, Sang-Geon MD, PhD∥; Choi, Miyoung PhD¶; Song, Yoo Sung MD, PhD†
From the ∗Department of Nuclear Medicine, CHA Bundang Medical Center, CHA University, Pocheon
†Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam
‡Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul
§Department of Health Science and Technology, The Graduate School of Convergence Science and Technology, Seoul National University, Suwon
∥Department of Nuclear Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju
¶Division for Healthcare Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, South Korea.
Correspondence to: Yoo Sung Song, MD, PhD
Abstract
Background: This meta-analysis and systematic review assessed the diagnostic accuracy of lung SPECT compared with lung planar imaging in patients with suspected acute pulmonary embolism (PE) or chronic thromboembolic pulmonary hypertension.
Patients and methods: A search of Medline, Embase, and Cochrane databases identified suitable articles published before October 2023. Meta-analyses were performed to determine the diagnostic accuracy of SPECT imaging modalities, including perfusion (Q) SPECT, ventilation (V)/Q SPECT, Q SPECT/CT, and V/Q SPECT/CT. Network meta-analyses were performed to compare the diagnostic accuracy of SPECT and planar imaging in paired-design studies.
Results: Twenty-four articles (total n = 6576) were included in the analysis. For suspected acute PE, the respective sensitivity and specificity of SPECT imaging modalities were as follows: Q SPECT, 0.93 (95% confidence interval [CI], 0.87-0.99; I2 = 49%) and 0.72 (95% CI, 0.54-0.95; I2 = 94%); V/Q SPECT, 0.96 (95% CI, 0.94-0.98; I2 = 51%) and 0.95 (95% CI, 0.92-0.98; I2 = 80%); Q SPECT/CT, 0.93 (95% CI, 0.87-0.98; I2 = 66%) and 0.82 (95% CI, 0.70-0.96; I2 = 87%); and V/Q SPECT/CT, 0.97 (95% CI, 0.93-1.00; I2 = 7%) and 0.98 (95% CI, 0.97-1.00; I2 = 31%). The relative sensitivity and specificity of SPECT compared with planar imaging were 1.17 (95% CI, 1.06-1.30; P < 0.001) and 1.14 (95% CI, 1.00-1.29; P = 0.05), respectively. For suspected chronic thromboembolic pulmonary hypertension, the pooled sensitivity and specificity of SPECT imaging were 0.97 (95% CI, 0.95-1.00; I2 = 0%) and 0.91 (95% CI, 0.87-0.94; I2 = 0%), respectively.
Conclusions: SPECT exhibited superior diagnostic performance for PE. V/Q SPECT/CT was the most accurate modality.
논문정보
- Research article
- 2024년 06월 (BRIC 등록일 2024-06-18)
- 국내 연구진
- 의약학 > 의약학 기타
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