오덕환 (강원대학교)

한빛사논문

조회273

강원대학교

CV File 171 kb

Crit. Rev. Food Sci. Nutr., Jun 04 2024, | https://doi.org/10.1080/10408398.2024.2362412 Unraveling the gut microbiota's role in Rheumatoid arthritis: dietary pathways to modulation and therapeutic potential

LingYue Shan^1,2, Ramachandran Chelliah ^1,2, Syed Mohammad Ehsanur Rahman ^1,3, Deog Hwan Oh ^1,2

¹Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, Republic of South Korea.

²Future F Biotech Co., Ltd, Chuncheon, Republic of South Korea.

³Department of Animal Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.

Correspondence : Deog Hwan Oh

Abstract

Rheumatoid arthritis (RA) is a significant global health issue. Recent research highlights the gut microbiota's critical role in RA's development, noting how dietary factors can alter these microbial communities. This has led to an increased focus on how the gut microbiota (GM) influences RA and the potential for dietary ingredients to offer anti-RA benefits by modifying GM. This review presents a concise examination of the GM associated with RA, identifying specific microbial taxa at various levels that are implicated in the disease. It delves into dietary components known for their anti-RA properties through GM modulation and their mechanisms. Findings from numerous studies, including both animal and human research, show significant differences in the GM composition between individuals with early and established RA. Certain microbes like Tenericutes, Synergistetes, and Proteobacteria have been linked to RA progression, whereas Bacteroidetes and some strains of Lactobacillus are shown to have protective effects against RA. Dietary elements such as fibers, polysaccharides, resistant starch, and peptides have been identified as influential in combating RA. These components work by altering the GM's metabolites and impacting immune cells related to the GM. This review suggests the potential for developing functional foods aimed at treating RA by targeting GM.

논문정보

형식Review Paper
게재일2024년 06월 (BRIC 등록일 2024-06-05)
연구진국내(교신)+국외 연구진
분야 생명과학 > 식품학

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