Xiao Chen (JINIS Biopharmaceuticals Inc) | 한빛사논문 > 한빛사

상위피인용논문

조회264

Xiao ChenXiao Chen

JINIS Biopharmaceuticals Inc

Protein Cell, 2013 Jun;4(6):403-14 | https://doi.org/10.1007/s13238-013-3017-x The role of gut microbiota in the gut-brain axis: current challenges and perspectives

Xiao Chen,¹ Roshan D’Souza,² and Seong-Tshool Hong^1,*

¹BDRD Research Institute, JINIS Biopharmaceuticals Inc, 948-9 Dunsan, Bongdong, Wanju, Chonbuk, 565-902 South Korea

²Department of Microbiology and Genetics and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, 561-712 South Korea

^*Corresponding author: correspondence to Seong-Tshool Hong

Abstract

Brain and the gastrointestinal (GI) tract are intimately connected to form a bidirectional neurohumoral communication system. The communication between gut and brain, knows as the gut-brain axis, is so well established that the functional status of gut is always related to the condition of brain. The researches on the gut-brain axis were traditionally focused on the psychological status affecting the function of the GI tract. However, recent evidences showed that gut microbiota communicates with the brain via the gut-brain axis to modulate brain development and behavioral phenotypes. These recent findings on the new role of gut microbiota in the gut-brain axis implicate that gut microbiota could associate with brain functions as well as neurological diseases via the gut-brain axis. To elucidate the role of gut microbiota in the gut-brain axis, precise identification of the composition of microbes constituting gut microbiota is an essential step. However, identification of microbes constituting gut microbiota has been the main technological challenge currently due to massive amount of intestinal microbes and the difficulties in culture of gut microbes. Current methods for identification of microbes constituting gut microbiota are dependent on omics analysis methods by using advanced high tech equipment. Here, we review the association of gut microbiota with the gut-brain axis, including the pros and cons of the current high throughput methods for identification of microbes constituting gut microbiota to elucidate the role of gut microbiota in the gut-brain axis.

논문정보

형식Review Paper
게재일2013년 06월 (BRIC 등록일 2024-06-05)
연구진국내 연구진
분야 생명과학 > 미생물학
피인용횟수120회 이상 인용된 논문

댓글 작성 로그인

CV 열람하기

연락처 보기