한빛사논문
- 조회470
KAIST, 현 POSTECH
Gihyun Lee 1, Soo Jee Kim 1, Je-Kyun Park 1,2,3
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
2KAIST Institute for Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
3KAIST Institute for Nanocentury, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
CORRESPONDING AUTHOR : Je-Kyun Park
Abstract
Current organ-on-a-chip technologies confront limitations in effectively recapitulating the intricate in vivo microenvironments and accommodating diverse experimental conditions on a single device. Here, we present a novel approach for constructing a multi-composition tumor array on a single microfluidic device, mimicking complex transport phenomena within tumor microenvironments (TMEs) and allowing for simultaneous evaluation of drug efficacy across 12 distinct conditions. The TME array formed by bioprinting on a microfluidic substrate consists of 36 individual TME models, each characterized by one of three different compositions and tested under four varying drug concentrations. Notably, the TME model exhibits precise compartmentalization, fostering the development of self-organized vascular endothelial barriers surrounding breast cancer spheroids affecting substance transport. Multivariable screening and analysis of diverse conditions, including model complexity, replicates, and drug concentrations, within a single microfluidic platform, highlight the synergistic potential of integrating bioprinting with microfluidics to evaluate drug responses across diverse TME conditions comprehensively.
논문정보
- Research article
- 2024년 06월 (BRIC 등록일 2024-06-04)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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