한빛사
>
한빛사논문
한빛사논문
- 조회99
김미영Mi-Young Kim
전북대학교, St George’s University of London
Trends Biotechnol., Jun 01 2024, S0167-7799(24)00123-9 | https://doi.org/10.1016/j.tibtech.2024.05.004
Recombinant immune complexes as vaccines against infectious diseases
Mi-Young Kim 1,2, Hugh S. Mason 3,4, Julian K.C. Ma 1,5, Rajko Reljic 1
1St. George’s University of London, London, UK
2Jeonbuk National University, Jeonju, South Korea
3School of Life Sciences, Arizona State University, Tempe, AZ, USA
Correspondence: Rajko Reljic
Abstract
New vaccine technologies are needed to combat many existing infections and prepare better for those that may emerge in the future. The conventional technologies that rely on protein-based vaccines are still severely restricted by the sparsity and poor accessibility of available adjuvants. One possible solution to this problem is to enhance antigen immunogenicity by a more natural means by complexing it with antibodies in the form of immune complexes (ICs). However, natural ICs are impractical as vaccines, and significant research efforts have been made to generate them in recombinant form, with plant bioengineering being at the forefront of these efforts. Here, we describe the challenges and progress made to date to make recombinant IC vaccines applicable to humans.
논문정보
- Review Paper
- 2024년 06월 (BRIC 등록일 2024-06-18)
- 국내+국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
