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Exp. Mol. Med., Jun 03 2024, | https://doi.org/10.1038/s12276-024-01254-7
Transcriptional regulation of Tfh dynamics and the formation of immunological synapses
Ye-Ji Kim1,5, Jinyong Choi2,5 and Youn Soo Choi1,3,4
1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
2Department of Microbiology, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea.
3Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.
4Transplantation Research Institute, Seoul National University Hospital, Seoul, Korea.
5These authors contributed equally: Ye-Ji Kim, Jinyong Choi.
Corresponding author
Correspondence to Youn Soo Choi.
Abstract
Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark and light zones to clonally expand, undergo affinity maturation, and differentiate into long-lived plasma cells or memory B cells. Follicular helper T (Tfh) cells, the key gatekeepers of GC-dependent humoral immunity, exhibit remarkable dynamic positioning within secondary lymphoid tissues and rely on intercellular interactions with antigen-presenting cells (APCs) during their differentiation and execution of B-cell-facilitating functions within GCs. In this review, we briefly cover the transcriptional regulation of Tfh cell differentiation and function and explore the molecular mechanisms governing Tfh cell motility, their interactions with B cells within GCs, and the impact of their dynamic behavior on humoral responses.
논문정보
- Review Paper
- 2024년 06월 (BRIC 등록일 2024-06-03)
- 국내 연구진
- 의약학 > 면역의학
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