한빛사논문
- 조회405
Su Hwan Park1,10, Jin-Sung Ju2,10, Hyunmin Woo3,10, Hye Jin Yun1, Su Bin Lee1, Seok-Ho Kim1,4, Balázs Győrffy5,6,7, Eun-jeong Kim3, Ho Kim8, Hee Dong Han9, Seong-il Eyun3, Jong-Ho Lee1 and Yun-Yong Park3
1Department of Health Sciences, The Graduate School of Dong-A University, Busan, Republic of Korea.
2Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
3Department of Life Science, Chung-Ang University, Seoul, Republic of Korea.
4Department of Medicinal Biotechnology, College of Health Science, Dong-A University, Busan, Republic of Korea.
5Department of Bioinformatics, Semmelweis University, H-1094 Budapest, Hungary.
6Department of Biophysics, Medical School, University of Pecs, H-7624 Pecs, Hungary.
7Cancer Biomarker Research Group, Institute of Molecular Life Sciences, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
8Division of Life Science and Chemistry, College of Natural Science, Daejin University, Pocheon, Republic of Korea.
9Department of Immunology, School of Medicine, Konkuk University, Chungcheongbuk-Do, Republic of Korea.
10These authors contributed equally: Su Hwan Park, Jin-Sung Ju, Hyunmin Woo.
Corresponding authors
Correspondence to Seong-il Eyun, Jong-Ho Lee or Yun-Yong Park.
Abstract
N6-adenosine methylation (m6A) is critical for controlling cancer cell growth and tumorigenesis. However, the function and detailed mechanism of how m6A methyltransferases modulate m6A levels on specific targets remain unknown. In the current study, we identified significantly elevated levels of RBM15, an m6A writer, in basal-like breast cancer (BC) patients compared to nonbasal-like BC patients and linked this increase to worse clinical outcomes. Gene expression profiling revealed correlations between RBM15 and serine and glycine metabolic genes, including PHGDH, PSAT1, PSPH, and SHMT2. RBM15 influences m6A levels and, specifically, the m6A levels of serine and glycine metabolic genes via direct binding to target RNA. The effects of RBM15 on cell growth were largely dependent on serine and glycine metabolism. Thus, RBM15 coordinates cancer cell growth through altered serine and glycine metabolism, suggesting that RBM15 is a new therapeutic target in BC.
논문정보
- Research article
- 2024년 06월 (BRIC 등록일 2024-06-03)
- 국내(교신)+국외 연구진
- 생명과학 > 분자생물학
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