한빛사논문
- 조회264
울산대학교 의과대학, 서울아산병원
Myoung Eun Choi,1 Eun Ji Choi,1 Jeong Hyeon Lee,2 Chong Hyun Won,1 Sung Eun Chang,1 Mi Woo Lee 1 and Woo Jin Lee 1*
1Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
2Department of biomedical science, Bio-Medical Institute of Technology (BMIT), University of Ulsan College of Medicine, Ulsan, Korea
*Corresponding author: Woo Jin Lee
Abstract
Background: Amelanotic acral melanoma (AAM) is a rare type of acral melanoma associated with poor prognosis.
Objectives: We aimed to investigate the transcriptomic differences between AAM and pigmented acral melanoma (PAM).
Methods: The differences in spatially resolved transcriptome profiles of 9 AAM patients with 29 regions of interest (ROIs) and 11 PAM patients with 46 ROIs were investigated using S100b and CD3 morphology markers.
Results: In S100b-positive tumor cell areas, we detected 11 upregulated differentially expressed genes (DEGs), including chaperone/ubiquitin-associated DEGs, and 82 downregulated DEGs, including human leukocyte antigen, in AAMs compared with PAMs. Protein-protein interaction network and pathway analyses revealed significant enrichment of dysregulated translational and nonsense-mediated decay pathways but significant decreases in antigen processing and presentation, interferon signaling, and melanin biosynthesis pathways in S100b-positive ROIs of AAMs compared with those of PAMs. In tumor-associated immune cell areas, the numbers of CD8 T cells (p = 0.044) and M1 macrophages (p = 0.014) were significantly decreased, whereas those of monocytes (p = 0.045) and endothelial cells (p = 0.04) were increased in AAMs compared with those in PAMs.
Conclusions: In conclusion, these findings could widen our understanding of the biological differences between AAMs and PAMs that might result in a different clinical course.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-06-04)
- 국내 연구진
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