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한국과학기술연구원(KIST)

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Adv. Healthc. Mater., May 30 2024, | https://doi.org/10.1002/adhm.202400475 Imaging-based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids

Seong-Eun Kim¹, Suji Yun², Junsang Doh^2,3*and Hong Nam Kim^1,4,5,6*

¹Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792 South Korea

²Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, 08826 South Korea

³Department of Materials Science and Engineering, Research Institute of Advanced Materials, Institute of Engineering Research, Bio-MAX institute, Soft Foundry Institute, Seoul National University, Seoul, 08826 South Korea

⁴Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792 Republic of Korea

⁵School of Mechanical Engineering, Yonsei University, Seoul, 03722 Republic of Korea

⁶Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul, 03722 Republic of Korea

CORRESPONDING AUTHORS : Junsang Doh, Hong Nam Kim

Abstract

Cancer immunotherapy is used to treat tumors by modulating the immune system. Although the anticancer efficacy of cancer immunotherapy has been evaluated prior to clinical trials, conventional in vivo animal and endpoint models inadequately replicate the intricate process of tumor elimination and reflect human-specific immune systems. Therefore, more sophisticated models that mimic the complex tumor-immune microenvironment must be employed to assess the effectiveness of immunotherapy. Additionally, using real-time imaging technology, a step-by-step evaluation can be applied, allowing for a more precise assessment of treatment efficacy. Here, we present an overview of the various imaging-based evaluation platforms recently developed for cancer immunotherapeutic applications. Specifically, we discuss a fundamental technique for stably observing immune cell-based tumor cell killing using direct imaging, a microwell that reproduces a confined space for spatial observation, a droplet assay that facilitates cell-cell interactions, and a three-dimensional microphysiological system that reconstructs the vascular environment. Furthermore, we suggest that future evaluation platforms pursue more human-like immune systems. This article is protected by copyright. All rights reserved.

논문정보

형식Review Paper
게재일2024년 05월 (BRIC 등록일 2024-05-31)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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