한빛사논문
- 조회188
Jee Hoon Roh 1,2, Inha Jung 1, Yunsun Suh 1,3, Min-Ho Kim 4
1Department of Biomedical Sciences and Department of Physiology, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
2Department of Neurology, Anam Hospital, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
3Steinhardt School of Culture, Education, and Human Development, New York University, NY, 10003, USA.
4Informatization Department, Ewha Womans University Seoul Hospital, Seoul, 07804, Republic of Korea.
To whom correspondence should be addressed. : Jee Hoon Roh, M.D., Ph.D.
Abstract
Background: The challenges of the COVID-19 pandemic extend to concerns about vaccine side effects, particularly potential links to neurodegenerative diseases such as Alzheimer's disease (AD).
Aim: This study investigates the association between COVID-19 vaccination and the onset of AD and its prodromal state, mild cognitive impairment (MCI).
Design: A nationwide, retrospective cohort study leveraging data from the Korean National Health Insurance Service was conducted.
Methods: The study, conducted in Seoul, South Korea, analyzed data from a random 50% sample of city residents aged 65 and above, totaling 558,017 individuals. Participants were divided into vaccinated and unvaccinated groups, with vaccinations including mRNA and cDNA vaccines. The study focused on AD and MCI incidences post-vaccination, identified via ICD-10 codes, using multivariable logistic and Cox regression analyses. Patients with vascular dementia or Parkinson's disease served as controls.
Results: Findings showed an increased incidence of MCI and AD in vaccinated individuals, particularly those receiving mRNA vaccines, within three months post-vaccination. The mRNA vaccine group exhibited a significantly higher incidence of AD (Odds Ratio [OR]: 1.225; 95% Confidence Interval [CI]: 1.025-1.464; p = 0.026) and MCI (OR: 2.377; CI: 1.845-3.064; p < 0.001) compared to the unvaccinated group. No significant relationship was found with vascular dementia or Parkinson's disease.
Conclusions: Preliminary evidence suggests a potential link between COVID-19 vaccination, particularly mRNA vaccines, and increased incidences of AD and MCI. This underscores the need for further research to elucidate the relationship between vaccine-induced immune responses and neurodegenerative processes, advocating for continuous monitoring and investigation into the vaccines' long-term neurological impacts.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-07-04)
- 국내(교신)+국외 연구진
- 의약학 > 신경의학
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