한빛사논문
- 조회364
Yujin Choi 1,2,14, Hyeon Jin Kim 1,3,14, Jaeyu Park 1,3,14, Myeongcheol Lee 1,3, Sunyoung Kim 4, Ai Koyanagi 5, Lee Smith 6, Min Seo Kim 7, Masoud Rahmati 8,9,10, Hayeon Lee 1,15, Jiseung Kang 11,12,15 & Dong Keon Yon 1,3,13,15
1Center for Digital Health, Medical Science research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
2Department of Korean Medicine, Kyung Hee University College of Korean Medicine, Seoul, South Korea.
3Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.
4Departmentof Family Medicine, KyungHee University Medical Center, KyungHee University College of Medicine, Seoul, South Korea.
5Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain.
6Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
7Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
8CEReSS Health Service Research and Quality of Life Center, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille University, Marseille, France.
9Department of Physical Education and Sport Sciences, Faculty of Literature andHumanities,Vali-E-AsrUniversityofRafsanjan,Rafsanjan,Iran.
10Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
11Division of Sleep Medicine, Harvard Medical School, Boston,MA, USA.
12Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
13Department of Pediatrics, Kyung Hee University Medical Center, KyungHee University College of Medicine, Seoul, South Korea.
14These authors contributed equally: Yujin Choi, Hyeon Jin Kim, Jaeyu Park.
15These authors jointly supervised this work: Hayeon Lee, Jiseung Kang, Dong Keon Yon.
Corresponding authors
Correspondence to Hayeon Lee, Jiseung Kang or Dong Keon Yon.
Abstract
Considering the significant burden of post-acute COVID-19 conditions among patients infected with SARS-CoV-2, we aimed to identify the risk of acute respiratory complications or post-acute respiratory sequelae. A binational population-based cohort study was conducted to analyze the risk of acute respiratory complications or post-acute respiratory sequelae after SARS-CoV-2 infection. We used a Korean nationwide claim-based cohort (K-COV-N; n = 2,312,748; main cohort) and a Japanese claim-based cohort (JMDC; n = 3,115,606; replication cohort) after multi-to-one propensity score matching. Among 2,312,748 Korean participants (mean age, 47.2 years [SD, 15.6]; 1,109,708 [48.0%] female), 17.1% (394,598/2,312,748) were infected with SARS-CoV-2. The risk of acute respiratory complications or post-acute respiratory sequelae is significantly increased in people with SARS-CoV-2 infection compared to the general population (acute respiratory complications: HR, 8.06 [95% CI, 6.92-9.38]; post-acute respiratory sequelae: 1.68 [1.62-1.75]), and the risk increased with increasing COVID-19 severity. We identified COVID-19 vaccination as an attenuating factor, showing a protective association against acute or post-acute respiratory conditions. Furthermore, while the excess post-acute risk diminished with time following SARS-CoV-2 infection, it persisted beyond 6 months post-infection. The replication cohort showed a similar pattern in the association. Our study comprehensively evaluates respiratory complications in post-COVID-19 conditions, considering attenuating factors such as vaccination status, post-infection duration, COVID-19 severity, and specific respiratory conditions.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-05-28)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 다학제 융합/복합
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