이기욱 (성균관대학교) | 한빛사논문 > 한빛사

한빛사논문

조회292

성균관대학교

Int. J. Antimicrob. Agents, Apr 30 2024, S0924-8579(24)00105-5 | https://doi.org/10.1016/j.ijantimicag.2024.107187 3-Fucosyllactose-Mediated Modulation of Immune Response against Virus Infection

Seokoh Moon^a,#, Ki Wook Lee ^a,#, Myungseo Park ^a, Jeonghui Moon ^a, Sang Hee Park ^a, Soomin Kim ^a, Jaehyeon Hwang ^a, Jong-Won Yoon ^b, Seon-Min Jeon ^b, Jun-Seob Kim ^c, Young-Jun Jeon ^a, Dae-Hyuk Kweon^a,b

^aDepartment of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.

^bAdvanced Protein Technologies Corp., Suwon 16229, Republic of Korea

^cDepartment of Nano-Bioengineering, Incheon National University, Incheon, 22012, South Korea

^#Equal contribution

Correspondence : Jun-Seob Kim, Young-Jun Jeon, Dae-Hyuk Kweon

Abstract

Viral pathogens, particularly influenza and SARS-CoV-2, pose a significant global health challenge. Given the immunomodulatory properties of human milk oligosaccharides (HMOs), in particular 2′-fucosyllactose (2`-FL) and 3-fucosyllactose (3-FL), we investigated their dietary supplementation effects on antiviral responses in mouse models. This study revealed distinct immune modulations induced by 3-FL. RNA-sequencing data showed that 3-FL increased the expression of interferon receptors, such as IFNAR and IFNGR, while simultaneously downregulating interferons and interferon-stimulated genes (ISGs), an effect not observed with 2`-FL supplementation. Such modulation enhanced antiviral responses in both cell culture and animal models, while attenuating pre-emptive inflammatory responses. Nitric oxide concentrations in 3-FL-supplemented A549 cells and mouse lung tissues were elevated exclusively upon infection, reaching 5.8- and 1.9-fold increases over control groups, respectively. In addition, 3-FL promoted leukocyte infiltration into the site of infection upon viral challenge. 3-FL supplementation provided protective efficacy against lethal influenza challenge in mice. The demonstrated antiviral efficacy spanned multiple influenza strains and extended to SARS-CoV-2. In conclusion, 3-FL is a unique immunomodulator that helps protect the host from viral infection while suppressing inflammation prior to infection.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-05-28)
연구진국내 연구진
분야 생명과학 > 면역학

댓글 작성 로그인

CV 열람하기

연락처 보기