한빛사논문
- 조회201
Albertus Ivan Brilian 1,2,3, Sang Ho Lee 1,2, Agustina Setiawati 1,2,4, Chang Ho Kim 1,2, Soo Ryeon Ryu 1,2, Hyo-Jin Chong 5,6, Yejin Jo 5,6, Hayan Jeong 5,6, Bong-Gun Ju 5,6, Oh-Sun Kwon 1,2, Giyoong Tae 7,8*, Kwanwoo Shin 1,2*
1Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 04107, Republic of Korea.
2Department of Chemistry and Institute of Biological Interfaces, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul, 04107, Republic of Korea.
3Faculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta, 55284, Indonesia.
4Faculty of Pharmacy, Sanata Dharma University, Yogyakarta, 55284, Indonesia.
5Department of Life Science, Sogang University, Seoul, 04107, Republic of Korea.
6Department of Life Science, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul, 04107, Republic of Korea.
7School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
8School of Materials Science and Engineering, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea.
*CORRESPONDING AUTHORS : Giyoong Tae, Kwanwoo Shin
Abstract
Collagen is a complex, large protein molecule that presents a challenge in delivering it to the skin due to its size and intricate structure. However, conventional collagen delivery methods are either invasive or may affect the protein's structural integrity. In this study, we introduce a novel approach involving the encapsulation of collagen monomers within zwitterionic nanoliposomes, termed Lip-Cols, and the controlled formation of collagen fibrils through electric fields (EF) stimulation. Our results reveal the self-assembly process of Lip-Cols through electroporation and a pH gradient change uniquely triggered by EF, leading to the alignment and aggregation of Lip-Cols on the electrode interface. Notably, Lip-Cols exhibit the capability to direct the orientation of collagen fibrils within human dermal fibroblasts. In conjunction with EF, Lip-Cols can deliver collagen into the dermal layer and increase the collagen amount in the skin. Our findings provide novel insights into the directed formation of collagen fibrils via electrical stimulation and the potential of Lip-Cols as a non-invasive drug delivery system for anti-aging applications.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-06-13)
- 국내(교신)+국외 연구진
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