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성균관대학교

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J. Hazard. Mater., May 17 2024, 473 S0304-3894(24)01220-2 | https://doi.org/10.1016/j.jhazmat.2024.134641 Toxicity and speciation of inorganic arsenics and their adverse effects on in vivo endpoints and oxidative stress in the marine medaka Oryzias melastigma

Eunjin Byeon ^a, Haksoo Jeong ^a, Min-Sub Kim ^a, Seong Chan Yun ^a, Jin-Sol Lee ^b, Min-Chul Lee^c, Jin-Hyoung Kim ^d, Alaa El-Din Hamid Sayed ^e, Jun Bo ^f, Hyung Sik Kim ^b, Chulho Yoon ^g, Atsushi Hagiwara ^h, Yoshitaka Sakakura ^h, Jae-Seong Lee ^a

^aDepartment of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea

^bSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea

^cDepartment of Food & Nutrition, College of Bio-Nano Technology, Gachon University, Seongnam 13120, South Korea

^dDivision of Life Sciences, Korea Polar Research Institute, Incheon 21990, South Korea

^eDepartment of Zoology, Faculty of Science, Assiut University, 71516 Assiut, Egypt

^fLaboratory of Marine Biology and Ecology, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China

^gOchang Center, Korea Basic Science Institute, Cheongju 28119, South Korea

^hInstitute of Integrated Science and Technology, Graduate School of Fisheries Science and Environmental Sciences, Nagasaki University, Nagasaki 852-8521, Japan

Corresponding author : Jae-Seong Lee

Abstract

Here, we investigate the effects of acute and chronic exposure to arsenate (AsV) and arsenite (AsIII) in the marine medaka Oryzias melastigma. In vivo effects, biotransformation, and oxidative stress were studied in marine medaka exposed to the two inorganic arsenics for 4 or 28 days. An investigation of embryonic development revealed no effect on in vivo parameters, but the hatching rate increased in the group exposed to AsIII. Exposure to AsIII also caused the greatest accumulation of arsenic in medaka. For acute exposure, the ratio of AsV to AsIII was higher than that of chronic exposure, indicating that bioaccumulation of inorganic arsenic can induce oxidative stress. The largest increase in oxidative stress was observed following acute exposure to AsIII, but no significant degree of oxidative stress was induced by chronic exposure. During acute exposure to AsV, the increase in the enzymatic activity of glutathione-S-transferase (GST) was twice as high compared with exposure to AsIII, suggesting that GST plays an important role in the initial detoxification process. In addition, an RNA-seq-based ingenuity pathway analysis revealed that acute exposure to AsIII may be related to cell-cycle progression. A network analysis using differentially expressed genes also revealed a potential link between the generation of inflammatory cytokines and oxidative stress due to arsenic exposure.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-05-27)
연구진국내(교신)+국외 연구진
분야 생명과학 > 분류/생태/환경생물학

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