이수지 (경희대학교)

한빛사논문

조회282

이수지Sooji Lee

경희대학교

J. Med. Virol., Jun 2024, 96 (6) | https://doi.org/10.1002/jmv.29682 Global and regional burden of vaccine-associated facial paralysis, 1967-2023: Findings from the WHO international pharmacovigilance database

Yi Deun Jeong ¹, Kyeongmin Lee ^2,3, Sooji Lee ¹, Jaeyu Park ^2,3, Hyeon Jin Kim ^2,3, Jinseok Lee ⁴, Jiseung Kang ^5,6, Louis Jacob^7,8,9, Lee Smith ¹⁰, Masoud Rahmati ^11,12,13, Guillermo F. López Sánchez ¹⁴, Elena Dragioti^15,16, Yejun Son ^2,17, Soeun Kim ^2,17, Seung Geun Yeo¹⁸, Hayeon Lee^2,4, Dong Keon Yon ^1,2,3,17,19

¹Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.

²Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

³Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.

⁴Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.

⁵Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.

⁶Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

⁷Department of Physical Medicine and Rehabilitation, AP-HP, Université Paris Cité, Lariboisière-Fernand Widal Hospital, Paris, France.

⁸Epidemiology of Ageing and Neurodegenerative Diseases (EpiAgeing), Université Paris Cité, Inserm U1153, Paris, France.

⁹Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Barcelona, Spain.

¹⁰Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.

¹¹Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.

¹²Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran.

¹³Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France.

¹⁴Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain.

¹⁵Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

¹⁶Research Laboratory Psychology of Patients, Families, and Health Professionals, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece.

¹⁷Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.

¹⁸Department of Otolaryngology-Head & Neck Surgery, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

¹⁹Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

Yi Deun Jeong, Kyeongmin Lee, and Sooji Lee contributed equally to this study.

CORRESPONDING AUTHORS: Seung Geun Yeo, Hayeon Lee, Dong Keon Yon

Abstract

The scarce and conflicting data on vaccine-associated facial paralysis limit our understanding of vaccine safety on a global scale. Therefore, this study aims to evaluate the global burden of vaccine-associated facial paralysis and to identify the extent of its association with individual vaccines, thereby contributing to the development of a more effective vaccination program. We used data on vaccine-associated facial paralysis from 1967 to 2023 (total reports, n = 131 255 418 418) from the World Health Organization International Pharmacovigilance Database. Global reporting counts, reported odds ratios (ROR), and information components (ICs) were computed to elucidate the association between the 16 vaccines and the occurrence of vaccine-associated facial paralysis across 156 countries. We identified 26 197 reports (men, n = 10 507 [40.11%]) of vaccine-associated facial paralysis from 49 537 reports of all-cause facial paralysis. Vaccine-associated facial paralysis has been consistently reported; however, a pronounced increase in reported incidence has emerged after the onset of the coronavirus disease 2019 (COVID-19) pandemic, which is attributable to the COVID-19 mRNA vaccine. Most vaccines were associated with facial paralysis, with differing levels of association, except for tuberculosis vaccines. COVID-19 mRNA vaccines had the highest association with facial paralysis reports (ROR, 28.31 [95% confidence interval, 27.60-29.03]; IC, 3.37 [IC _0.25, 3.35]), followed by encephalitis, influenza, hepatitis A, papillomavirus, hepatitis B, typhoid, varicella-zoster, meningococcal, Ad-5 vectored COVID-19, measles, mumps and rubella, diphtheria, tetanus toxoids, pertussis, polio, and Hemophilus influenza type b, pneumococcal, rotavirus diarrhea, and inactivated whole-virus COVID-19 vaccines. Concerning age- and sex-specific risks, vaccine-associated facial paralysis was more strongly associated with older age groups and males. The serious adverse outcome and death rate of vaccine-associated facial paralysis were extremely low (0.07% and 0.00%, respectively). An increase in vaccine-induced facial paralysis, primarily owing to COVID-19 mRNA vaccines, was observed with most vaccines, except tuberculosis vaccines. Given the higher association observed in the older and male groups with vaccine-associated facial paralysis, close monitoring of these demographics when administering vaccines that are significantly associated with adverse reactions is crucial.

논문정보

형식Research article
게재일2024년 06월 (BRIC 등록일 2024-05-27)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 다학제 융합/복합

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