한빛사논문
- 조회629
Jingjing Wu 1, Jue Deng 1, Georgios Theocharidis 2, Tiffany L. Sarrafian 3, Leigh G. Griffiths 4, Roderick T. Bronson 5, Aristidis Veves 2, Jianzhu Chen 6, Hyunwoo Yuk 1,8,* & Xuanhe Zhao 1,7,*
1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
2Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
3Department of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
4Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
5Department of Immunology, Harvard Medical School, Boston, MA, USA.
6Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
7Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
8Present address: SanaHeal, Cambridge, MA, USA.
*Corresponding authors: correspondence to Hyunwoo Yuk or Xuanhe Zhao
Abstract
Implanted biomaterials and devices face compromised functionality and efficacy in the long term owing to foreign body reactions and subsequent formation of fibrous capsules at the implant–tissue interfaces. Here we demonstrate that an adhesive implant–tissue interface can mitigate fibrous capsule formation in diverse animal models, including rats, mice, humanized mice and pigs, by reducing the level of infiltration of inflammatory cells into the adhesive implant–tissue interface compared to the non-adhesive implant–tissue interface. Histological analysis shows that the adhesive implant–tissue interface does not form observable fibrous capsules on diverse organs, including the abdominal wall, colon, stomach, lung and heart, over 12 weeks in vivo. In vitro protein adsorption, multiplex Luminex assays, quantitative PCR, immunofluorescence analysis and RNA sequencing are additionally carried out to validate the hypothesis. We further demonstrate long-term bidirectional electrical communication enabled by implantable electrodes with an adhesive interface over 12 weeks in a rat model in vivo. These findings may offer a promising strategy for long-term anti-fibrotic implant–tissue interfaces.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-06-20)
- 국외 연구진
- 바이오·의료융합 > 바이오소재
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