강민지 (University of California, Los Angeles)

한빛사논문

조회250

강민지Minjee Kang

University of California, Los Angeles

CV File 172 kb

Adv. Funct. Mater., 19 May 2024 | https://doi.org/10.1002/adfm.202402521 Phosphatidylserine-Incorporated Exosome Mimetics Encapsulating CXCR3 Antagonist Alleviate Osteoporosis

Minjee Kang¹, Zhi Li¹, Insoon Chang², Changlu Xu¹, Michelle Chiang¹, Lauren Kim¹, Yutong Wu³, Jiabing Fan⁴, Tara Aghaloo^5*, and Min Lee^1,6*

¹Division of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA

²Division of Regenerative and Reconstructive Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA

³Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA

⁴Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, USA

⁵Division of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USAM. Lee

⁶Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA

CORRESPONDING AUTHORS : Tara Aghaloo, Min Lee

Abstract

Exosomes derived from mesenchymal stem cells are an active area of research due to their therapeutic potential in treating osteoporosis. To further harness their therapeutic performance in modulating bone resorption, equipped exosomes with osteoclast-targeting moieties on their surface as well as chemokine receptor antagonists blocking osteoclast recruitment. Phosphatidylserine (PS), a membrane lipid exerting immunosuppressive and phagocytic signals, is incorporated in the membrane of exosome mimetics (EMs) to achieve a marked affinity for osteoclast precursors and potential anti-resorptive effects. This is also aimed to tackle a CXCL9-CXCR3 ligand-receptor axis, a critical signaling axis in regulating osteoclast precursor recruitment and differentiation at bone resorption sites, by encapsulating a chemical antagonist of CXCR3, AMG487, in the PS-incorporated EMs (PS-EMs). The osteoclast-targeting PS-EMs loaded with AMG487 effectively protected against bone loss in an ovariectomized mouse model. These findings demonstrate the great promise of PS-EMs as anti-resorptive nanotherapies for alleviating osteoporosis.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-05-27)
연구진국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

댓글 작성 로그인

CV 열람하기

연락처 보기