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기초과학연구원, 서울대학교

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Nano Lett., May 21 2024, | https://doi.org/10.1021/acs.nanolett.4c01163 Stretchable Functional Nanocomposites for Soft Implantable Bioelectronics

Hye Jin Kim ^1‡, Heewon Choi ^2,3‡, Dae-Hyeong Kim ^4,5*, Donghee Son ^2,3,4*

¹Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea.

²Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, Republic of Korea.

³Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.

⁴Center for Nanoparticle Research, Institute for Basic Science, Seoul 08826, Republic of Korea.

⁵School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.

^‡H.J.K. and H.C. contributed equally to this paper.

^*Corresponding Authors : Dae-Hyeong Kim, Donghee Son

Abstract

Material advances in soft bioelectronics, particularly those based on stretchable nanocomposites─functional nanomaterials embedded in viscoelastic polymers with irreversible or reversible bonds─have driven significant progress in translational medical device research. The unique mechanical properties inherent in the stretchable nanocomposites enable stiffness matching between tissue and device, as well as its spontaneous mechanical adaptation to in vivo environments, minimizing undesired mechanical stress and inflammation responses. Furthermore, these properties allow percolative networks of conducting fillers in the nanocomposites to be sustained even under repetitive tensile/compressive stresses, leading to stable tissue-device interfacing. Here, we present an in-depth review of materials strategies, fabrication/integration techniques, device designs, applications, and translational opportunities of nanocomposite-based soft bioelectronics, which feature intrinsic stretchability, self-healability, tissue adhesion, and/or syringe injectability. Among many, applications to brain, heart, and peripheral nerves are predominantly discussed, and translational studies in certain domains such as neuromuscular and cardiovascular engineering are particularly highlighted.

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형식Review Paper
게재일2024년 05월 (BRIC 등록일 2024-05-22)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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