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National Institutes of Health

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Neurosci. Biobehav. Rev., May 16 2024, 162 S0149-7634(24)00188-X | https://doi.org/10.1016/j.neubiorev.2024.105719 Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease

Hyunchan Lee ^a, Hyoung F. Kim ^b, Okihide Hikosaka ^a

^aLaboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-4435, USA

^bSchool of Biological Sciences, College of Natural Sciences, Seoul National University (SNU), Seoul 08826, Republic of Korea

Corresponding author : Hyunchan Lee

Abstract

To improve the initiation and speed of intended action, one of the crucial mechanisms is suppressing unwanted movements that interfere with goal-directed behavior, which is observed relatively aberrant in Parkinson's disease patients. Recent research has highlighted that dopamine deficits in Parkinson's disease predominantly occur in the caudal lateral part of the substantia nigra pars compacta (SNc) in human patients. We previously found two parallel circuits within the basal ganglia, primarily divided into circuits mediated by the rostral medial part and caudal lateral part of the SNc dopamine neurons. We have further discovered that the indirect pathway in caudal basal ganglia circuits, facilitated by the caudal lateral part of the SNc dopamine neurons, plays a critical role in suppressing unnecessary involuntary movements when animals perform voluntary goal-directed actions. We thus explored recent research in humans and non-human primates focusing on the distinct functions and networks of the caudal lateral part of the SNc dopamine neurons to elucidate the mechanisms involved in the impairment of suppressing involuntary movements in Parkinson's disease patients.

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형식Review Paper
게재일2024년 05월 (BRIC 등록일 2024-05-20)
연구진국외 연구진
분야 바이오·의료융합 > 뇌인지과학

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