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경서연Seoyeon Kyung

경희대학교

J. Med. Virol., May 2024, 96 (5) | https://doi.org/10.1002/jmv.29668 Risks of alopecia areata in long COVID: Binational population-based cohort studies from South Korea and Japan

Seoyeon Kyung ^1,2, Yejun Son ^1,3, Minji Kim ^1,2, Jiseung Kang ^4,5, Lee Smith ⁶, Hayeon Lee ^1,7, Dong Keon Yon ^1,2,3,8

¹Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

²Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.

³Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.

⁴Harvard Medical School, Division of Sleep Medicine, Boston, Massachusetts, USA.

⁵Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

⁶Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.

⁷Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.

⁸Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

Seoyeon Kyung and Yejun Son contributed equally to this study. Hayeon Lee and Dong Keon Yon jointly supervised the work.

CORRESPONDING AUTHORS : Hayeon Lee, Dong Keon Yon

Abstract

Previous studies have proposed alopecia areata (AA) as a potential outcome of COVID-19 infection among autoimmune diseases, yet the findings might be inconclusive and difficult to generalize due to limited sample sizes and evidence levels. Thus, we aimed to investigate in detail the long-term risk of AA following SARS-CoV-2 infection based on large, binational, general population-based cohort studies. Our study investigated the long-term AA risk after SARS-CoV-2 infection by analyzing bi-national, claim-based cohorts in South Korea and Japan: a Korean nationwide cohort (K-COV-N cohort; discovery cohort; total n = 10 027 506) and a Japanese claims-based cohort (JMDC cohort; validation cohort; total n = 12 218 680). AA was identified based on the international classification of diseases 10th revision code (L63) requiring at least three claims within 1 year. After exposure-driven propensity score matching, SARS-CoV-2 infection was associated with an increased risk of incident AA (aHR, 1.66; 95% CI, 1.38-1.99). This increased risk was observed and persisted for up to 6 months. A similar pattern was observed in the validation cohort. As modifiable factors, severe COVID-19 increased the risk of AA, whereas receiving two or more doses of the COVID-19 vaccine before infection decreased the risk of AA. Through a bi-national cohort study in South Korea and Japan, SARS-CoV-2 infection was associated with an elevated risk for incident AA in the aspect of long COVID.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-05-20)
연구진국내(교신)+국외 연구진
분야 의약학 > 감염의학

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