김종승 (고려대학교)

한빛사논문

조회175

고려대학교

J. Control. Release, May 03 2024, 370 S0168-3659(24)00278-5 | https://doi.org/10.1016/j.jconrel.2024.04.049 Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds

Chang Xu ^a,1, Jin-Feng Cao^b,c,1, Yue Pei ^a, Yujin Kim ⁱ, Huiyeon Moon ⁱ, Chui-Qin Fan ^a, Mao-Chuan Liao ^a, Xing-Yu Wang ^h, Fei Yao^d, Yu-Jun Zhang^a, Shao-Hui Zhang ^e, Jian Zhang ^e, Jian-Zhang Li ^b,c, Jong Seung Kimⁱ, Lian Ma ^a,f,g, Zhong-Jian Xie ^a,j

^aInstitute of Pediatrics, Shenzhen Children's Hospital, Clinical Medical College of Southern University of Science and Technology, Shenzhen 518038, China

^bBeijing Key Laboratory of Wood Science and Engineering, Beijing Forestry University, Beijing 100083, China

^cKey Laboratory of Wood Material Science and Application (Beijing Forestry University), Ministry of Education, Beijing 100083, China

^dEye Center of Xiangya Hospital, Central South University, Changsha 410000, China

^eInstitute of Materials Science and Devices, School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China

^fDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen 518038, China

^gDepartment of Pediatrics, The Third Affifiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China

^hDepartment of Emergency, ChangYang Tujia Autonomous County People's Hospital, Yichang 443000, China

ⁱDepartment of Chemistry, Korea University, Seoul 02841, Republic of Korea

^jShenzhen International Institute for Biomedical Research, Shenzhen 518116, Guangdong, China

¹Contributed equally to this work.

Corresponding authors : Jian-Zhang Li, Jong Seung Kim, Lian Ma, Zhong-Jian Xie

Abstract

Chronic skin wounds are a serious complication of diabetes with a high incidence rate, which can lead to disability or even death. Previous studies have shown that mesenchymal stem cells derived extracellular vesicles (EVs) have beneficial effects on wound healing. However, the human foreskin mesenchymal stem cell (FSMSCs)-derived extracellular vesicle (FM-EV) has not yet been isolated and characterized. Furthermore, the limited supply and short lifespan of EVs also hinder their practical use. In this study, we developed an injectable dual-physical cross-linking hydrogel (PSiW) with self-healing, adhesive, and antibacterial properties, using polyvinylpyrrolidone and silicotungstic acid to load FM-EV. The EVs were evenly distributed in the hydrogel and continuously released. In vivo and vitro tests demonstrated that the synergistic effect of EVs and hydrogel could significantly promote the repair of diabetic wounds by regulating macrophage polarization, promoting angiogenesis, and improving the microenvironment. Overall, the obtained EVs-loaded hydrogels developed in this work exhibited promising applicability for the repair of chronic skin wounds in diabetes patients.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-05-22)
연구진국내(교신)+국외 연구진
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