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ACS Nano, May 10 2024, | https://doi.org/10.1021/acsnano.4c02578 Multifunctional and Flexible Neural Probe with Thermally Drawn Fibers for Bidirectional Synaptic Probing in the Brain

Yeji Kim¹, Yunheum Lee ¹, Jeongeun Yoo¹, Kum Seok Nam¹, Woojin Jeon¹, Seungmin Lee ¹, Seongjun Park ^1,2,3

¹Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-road, Yuseong-gu, Daejeon 34141, Republic of Korea.

²Department of Materials Science, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-road, Yuseong-gu, Daejeon 34141, Republic of Korea.

³KAIST Institute for NanoCentury (KINC), 291 Daehak-road, Yuseong-gu, Daejeon 34141, Republic of Korea.

Y.K. and Y.L. authors contributed equally.

Corresponding Author : Seongjun Park

Abstract

Synapses in the brain utilize two distinct communication mechanisms: chemical and electrical. For a comprehensive investigation of neural circuitry, neural interfaces should be capable of both monitoring and stimulating these types of physiological interactions. However, previously developed interfaces for neurotransmitter monitoring have been limited in interaction modality due to constraints in device size, fabrication techniques, and the usage of flexible materials. To address this obstacle, we propose a multifunctional and flexible fiber probe fabricated through the microwire codrawing thermal drawing process, which enables the high-density integration of functional components with various materials such as polymers, metals, and carbon fibers. The fiber enables real-time monitoring of transient dopamine release in vivo, real-time stimulation of cell-specific neuronal populations via optogenetic stimulation, single-unit electrophysiology of individual neurons localized to the tip of the neural probe, and chemical stimulation via drug delivery. This fiber will improve the accessibility and functionality of bidirectional interrogation of neurochemical mechanisms in implantable neural probes.

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형식Research article
게재일2024년 05월 (BRIC 등록일 2024-05-13)
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