신수련 (Harvard Medical School/Brigham and Women’s Hospital)

한빛사논문

조회268

Harvard Medical School/Brigham and Women’s Hospital

CV File 628 kb

Small, May 11 2024, | https://doi.org/10.1002/smll.202312261 Injectable Self-Oxygenating Cardio-Protective and Tissue Adhesive Silk-Based Hydrogel for Alleviating Ischemia After Mi Injury

Shabir Hassan^1,2,3, Zahra Rezaei ^1,4, Eder Luna ¹, Dilara Yilmaz-Aykut ^1,5, Myung Chul Lee ^1,6, Ana Marie Perea ^1,7, Anurag Jamaiyar ⁸, Nicole Bassous ¹, Minoru Hirano ^1,9, Fatima Mumtaza Tourk^1,10, Cholong Choi ¹, Malin Becker ¹¹, Iman Yazdi ¹², Kai Fan ^1,13, Alan Eduardo Avila-Ramirez ^1,14, David Ge¹, Reza Abdi ¹⁵, Sudeshna Fisch ⁸, Jeroen Leijten ¹¹, Mark W Feinberg ⁸, Biman B Mandal ^16,17,18, Ronglih Liao ^19,20, Su Ryon Shin¹

¹Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, United States.

²Department of Biological Sciences, Khalifa University, Shakhbout Bin Sultan St, Abu Dhabi, 127788, United Arab Emirates.

³Biotechnology Center (BTC), Khalifa University, Shakhbout Bin Sultan St, Abu Dhabi, 127788, United Arab Emirates.

⁴Department of Chemical Engineering, Sharif University of Technology, Tehran, 1365-11155, Iran.

⁵Department of Chemical Engineering, Faculty of Engineering, Istanbul University-Cerrahpaşa, Istanbul, 34320, Turkey.

⁶Biomedical Research Division, Medicinal Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea.

⁷School of Science and Engineering, Technologico de Monterrey, Monterrey, Mexico.

⁸Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

⁹Future Vehicle Research Department, Toyota Research Institute North America, Toyota Motor North America, Inc., 1555 Woodridge Ave., Ann Arbor, MI, 48105, USA.

¹⁰Department of Mechanical Engineering, Northeastern University, Boston, MA, 02115, USA.

¹¹Department of BioEngineering Technologies, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands.

¹²School of Arts and Sciences, Regis College, 235 Wellesley Street, Weston, MA, 02493, USA.

¹³School of Automation, Hangzhou Dianzi, Hangzhou, Zhejiang, 310018, China.

¹⁴Division of Biological and Environmental Science Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.

¹⁵Transplantation Research Center, Renal Division, Brigham and Women's Hospital / Harvard Medical School, Boston, MA, 02115, USA.

¹⁶Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.

¹⁷Center for nanotechnology, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam, 781039, India.

¹⁸Jyoti and Bhupat Mehta School of health Sciences and Technology, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam, 781039, India.

¹⁹School of Medicine, Stanford University, Stanford, CA, 94305-5101, USA.

²⁰Stanford Amyloid Center, Stanford University, Stanford, CA, 94305-5101, USA.

CORRESPONDING AUTHOR : Su Ryon Shin

Abstract

Myocardial infarction (MI) is a significant cardiovascular disease that restricts blood flow, resulting in massive cell death and leading to stiff and noncontractile fibrotic scar tissue formation. Recently, sustained oxygen release in the MI area has shown regeneration ability; however, improving its therapeutic efficiency for regenerative medicine remains challenging. Here, a combinatorial strategy for cardiac repair by developing cardioprotective and oxygenating hybrid hydrogels that locally sustain the release of stromal cell-derived factor-1 alpha (SDF) and oxygen for simultaneous activation of neovascularization at the infarct area is presented. A sustained release of oxygen and SDF from injectable, mechanically robust, and tissue-adhesive silk-based hybrid hydrogels is achieved. Enhanced endothelialization under normoxia and anoxia is observed. Furthermore, there is a marked improvement in vascularization that leads to an increment in cardiomyocyte survival by ≈30% and a reduction of the fibrotic scar formation in an MI animal rodent model. Improved left ventricular systolic and diastolic functions by ≈10% and 20%, respectively, with a ≈25% higher ejection fraction on day 7 are also observed. Therefore, local delivery of therapeutic oxygenating and cardioprotective hydrogels demonstrates beneficial effects on cardiac functional recovery for reparative therapy.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-05-13)
연구진국내+국외 연구진
분야 바이오·의료융합 > 바이오소재

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