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Adv. Healthc. Mater., May 08 2024, | https://doi.org/10.1002/adhm.202304496
Advanced Immunomodulatory Biomaterials for Therapeutic Applications
Ji-Eun Park 1, Dong-Hwee Kim 1,2,3
1KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
2Department of Integrative Energy Engineering, College of Engineering, Korea University, Seoul, 02841, Republic of Korea.
3Biomedical Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
CORRESPONDING AUTHOR : Dong-Hwee Kim
Abstract
The multifaceted biological defense system modulating complex immune responses against pathogens and foreign materials plays a critical role in tissue homeostasis and disease progression. Recently developed biomaterials that could specifically regulate immune responses, nanoparticles, graphene, and functional hydrogels have contributed to the advancement of tissue engineering as well as disease treatment. The interaction between innate and adaptive immunity, collectively determining immune responses, can be regulated by mechanobiological recognition and adaptation of immune cells to the extracellular microenvironment. Therefore, applying immunomodulation to tissue regeneration and cancer therapy involves manipulating the properties of biomaterials by tailoring their composition in the context of the immune system. In this review, we provide a comprehensive overview of how the physicochemical attributes of biomaterials determine immune responses, focusing on the physical properties that influence innate and adaptive immunity. This review also underscores the critical aspect of biomaterial-based immune engineering for the development of novel therapeutics and emphasizes the importance of understanding the biomaterials-mediated immunological mechanisms and their role in modulating the immune system. This article is protected by copyright. All rights reserved.
논문정보
- Review Paper
- 2024년 05월 (BRIC 등록일 2024-05-09)
- 국내 연구진
- 생명과학 > 세포생물학
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