한빛사논문
- 조회245
성균관대학교
Jun-Hyeok Han a,b,1, Hee Seung Seo b,c,1, Jiyoung Lee d,1, Zheng Chen d,1, Qiyue Wang e,f, Yun Young Lee c,g, Na Kyeong Lee b,c, Jeon Min Kang h, Song Hee Kim h, Hwichan Hong i, Jung-Hoon Park h, Yuanzhe Piao i,j, Fangyuan Li d,f,p, Kun Na k,l, Chun Gwon Park b,c,m,n, Wooram Park a,n,o, Daishun Ling d,e,f
aDepartment of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi 16419, Republic of Korea
bDepartment of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, SKKU, 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi 16419, Republic of Korea
cDepartment of Biomedical Engineering, SKKU Institute for Convergence, SKKU, 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi 16419, Republic of Korea
dInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China
eFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China
fWLA Laboratories, Shanghai 201203, China
gDepartment of Biomedical Engineering, Seoul National University College of Medicine, 103, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
hBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
iAdvanced Institutes of Convergence Technology, 145, Gwanggyo-ro, Yeongtong-gu, Suwon, Gyeonggi 16229, Republic of Korea
jDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, 145, Gwanggyo-ro, Yeongtong-gu, Suwon, Gyeonggi 16229, Republic of Korea
kDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi 14662, Republic of Korea
lDepartment of Biotechnology, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi 14662, Republic of Korea
mBiomedical Institute for Convergence at SKKU (BICS), SKKU, 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi 16419, Republic of Korea
nBiomaterials Research Center, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea
oDepartment of MetaBioHealth, SKKU Institute for Convergence, SKKU, 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi 16419, Republic of Korea
pSongjiang Research Institute, Songjiang Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China
1These authors have contributed equally to this work.
Corresponding authors: Chun Gwon Park, Wooram Park, Daishun Ling
Abstract
Ferroptosis, an iron-dependent regulated cell death pathway, has emerged as a promising modality for cancer therapy. However, current iron-based ferroptosis inducers, which trigger the Fenton reaction and release Fe2+, face challenges associated with limited cytosolic Fe2+ accumulation, leading to suboptimal ferroptosis induction. Herein, we report an electro-ferroptotic nanoammunition (EFN) composed of iron oxide nanoassembly (IONA) and ascorbic acid-loaded liposomes (Lip-AA) that enables image-guided, spatiotemporally controlled ferroptosis induction via irreversible electroporation (IRE) for enhanced cancer ferroptotic therapy. The IONA and Lip-AA form stable complexes through electrostatic interactions. Upon IRE stimulation, ascorbic acid is released from liposomes and reduce IONA to release abundant Fe2+. Moreover, IRE enhances tumor cell membrane permeability, thus facilitating efficient cytosolic Fe2+ accumulation for effective tumor ferroptosis. Notably, the Fe2+ release of EFN after IRE can be readily monitored by magnetic resonance imaging. Finally, IRE-triggered EFN demonstrates superior tumor growth inhibition, increased survival rates, and activation of immune cells, showing great potential for the development of next-generation spatiotemporally controlled ferroptotic therapies.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-05-09)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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