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김혜순Hae Soon Kim

이화여자대학교

BMC Med., May 07 2024, 22 (1) | https://doi.org/10.1186/s12916-024-03406-y A proposed simplified definition of metabolic syndrome in children and adolescents: a global perspective

Xin’nan Zong^1,2†, Roya Kelishadi^3†, Hae Soon Kim^4†, Peter Schwandt^5†, Tandi E. Matsha^6†, Jose G. Mill^7†, Carmelo Antonio Caserta^8†, Carla Campos Muniz Medeiros^9†, Anastasios Kollias^10†, Peter H. Whincup¹¹, Lucia Pacifco¹², Abel López‑Bermejo^13,14,15, Min Zhao^16*, Miaobing Zheng¹⁷ and Bo Xi^2*

¹Department of Growth and Development, Capital Institute of Pediatrics, Beijing, China.

²Department of Epidemiology, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

³Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

⁴Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea.

⁵Atherosclerosis Prevention Institute, Munich‑Nuremberg, Munich, Germany.

⁶Department of Biomedical Sciences, Faculty of Health & Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.

⁷Department of Physiological Sciences, Center of Health Sciences, Federal University of Espírito Santo, Vitória, Brazil.

⁸Associazione Calabrese Di Epatologia - Medicina Solidale - A.C.E. ETS, Reggio Calabria, Italy.

⁹Department of Public Health, State University of Paraiba, Campina Grande, Brazil.

¹⁰Hypertension Center STRIDE‑7, School of Medicine, Third Department of Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece.

¹¹Population Health Research Institute, St George’s, University of London, London, UK.

¹²Department of Maternal and Child Health, Sapienza University of Rome, Rome, Italy.

¹³Pediatric Endocrinology Research Group, Girona Biomedical Research Institute (IDIBGI), Salt, Spain.

¹⁴Department of Pediatrics, Hospital Dr. Josep Trueta, Girona, Spain.

¹⁵Department of Medical Sciences, University of Girona, Girona, Spain.

¹⁶Department of Nutrition and Food Hygiene, School of Public Health, Shandong University, Jinan, China.

¹⁷Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.

†Xin’nan Zong, Roya Kelishadi, Hae Soon Kim, Peter Schwandt, Tandi E. Matsha, Jose G. Mill, Carmelo Antonio Caserta, Carla Campos Muniz Medeiros and Anastasios Kollias contributed equally to this work.

^*Correspondence to Min Zhao or Bo Xi.

Abstract

Metabolic syndrome (MetS) is becoming prevalent in the pediatric population. The existing pediatric MetS definitions (e.g., the International Diabetes Federation (IDF) definition and the modified National Cholesterol Education Program (NCEP) definition) involve complex cut-offs, precluding fast risk assessment in clinical practice.We proposed a simplified definition for assessing MetS risk in youths aged 6-17 years, and compared its performance with two existing widely used pediatric definitions (the IDF definition, and the NCEP definition) in 10 pediatric populations from 9 countries globally (n = 19,426) using the receiver operating characteristic (ROC) curve analyses. In general, the total MetS prevalence of 6.2% based on the simplified definition was roughly halfway between that of 4.2% and 7.7% estimated from the IDF and NCEP definitions, respectively. The ROC curve analyses showed a good agreement between the simplified definition and two existing definitions: the total area under the curve (95% confidence interval) of the proposed simplified definition for identifying MetS risk achieved 0.91 (0.89-0.92) and 0.79 (0.78-0.81) when using the IDF or NCEP definition as the gold standard, respectively.The proposed simplified definition may be useful for pediatricians to quickly identify MetS risk and cardiometabolic risk factors (CMRFs) clustering in clinical practice, and allow direct comparison of pediatric MetS prevalence across different populations, facilitating consistent pediatric MetS risk monitoring and the development of evidence-based pediatric MetS prevention strategies globally.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-05-22)
연구진국내+국외 연구진
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