허윤석 (인하대학교)

한빛사논문

조회193

인하대학교

CV File 543 kb

Adv. Sci., May 07 2024, | https://doi.org/10.1002/advs.202401617 Advancements in Aptamer-Driven DNA Nanostructures for Precision Drug Delivery

Moein Safarkhani^{1 2}, Sepideh Ahmadi ¹, Hossein Ipakchi ³, Mohammad Reza Saeb ⁴, Pooyan Makvandi ^{5 6 7}, Majid Ebrahimi Warkiani ^{8 9 *}, Navid Rabiee ^{7 10 *}, YunSuk Huh ^{1 *}

¹NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, 100 Inha-ro, Incheon, 22212, Republic of Korea.

²School of Chemistry, Damghan University, Damghan, 36716-45667, Iran.

³Department of Chemical Engineering, McMaster University, Hamilton, L8S 4L8, Canada.

⁴Department of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, Gdańsk, 80-416, Poland.

⁵The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, 324000 Quzhou, Zhejiang, China.

⁶Centre of Research Impact and Outreach, Chitkara University, Rajpura, Punjab, 140417, India.

⁷Department of Biomaterials, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai, 600077, India.

⁸School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW, 2007, Australia.

⁹Institute for Biomedical Materials and Devices (IBMD), University of Technology Sydney, Sydney, NSW, 2007, Australia.

¹⁰Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, 6150, Australia.

^*Corresponding authors: correspondence to Ebrahimi Warkiani, Navid Rabiee or YunSuk Huh

Abstract

DNA nanostructures exhibit versatile geometries and possess sophisticated capabilities not found in other nanomaterials. They serve as customizable nanoplatforms for orchestrating the spatial arrangement of molecular components, such as biomolecules, antibodies, or synthetic nanomaterials. This is achieved by incorporating oligonucleotides into the design of the nanostructure. In the realm of drug delivery to cancer cells, there is a growing interest in active targeting assays to enhance efficacy and selectivity. The active targeting approach involves a "key-lock" mechanism where the carrier, through its ligand, recognizes specific receptors on tumor cells, facilitating the release of drugs. Various DNA nanostructures, including DNA origami, Tetrahedral, nanoflower, cruciform, nanostar, nanocentipede, and nanococklebur, can traverse the lipid layer of the cell membrane, allowing cargo delivery to the nucleus. Aptamers, easily formed in vitro, are recognized for their targeted delivery capabilities due to their high selectivity for specific targets and low immunogenicity. This review provides a comprehensive overview of recent advancements in the formation and modification of aptamer-modified DNA nanostructures within drug delivery systems.

논문정보

형식Review Paper
게재일2024년 05월 (BRIC 등록일 2024-07-11)
연구진국내(교신)+국외 연구진
분야 생명과학 > 생물공학

댓글 작성 로그인

CV 열람하기

연락처 보기