한빛사논문
- 조회689
Jiso Hong 1 2, Kyuhyun Choi 1, Marc V. Fuccillo 1, Shinjae Chung 1 2, Franz Weber 1 2 3 *
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
*Corresponding author: correspondence to Franz Weber
Abstract
Rapid eye movement (REM) sleep is known to facilitate fear extinction and play a protective role against fearful memories. Consequently, disruption of REM sleep after a traumatic event may increase the risk for developing PTSD. However, the underlying mechanisms by which REM sleep promotes extinction of aversive memories remain largely unknown. The infralimbic cortex (IL) is a key brain structure for the consolidation of extinction memory. Using calcium imaging, we found in mice that most IL pyramidal neurons are intensively activated during REM sleep. Optogenetically suppressing the IL specifically during REM sleep within a 4-h window after auditory-cued fear conditioning impaired extinction memory consolidation. In contrast, REM-specific IL inhibition after extinction learning did not affect the extinction memory. Whole-cell patch-clamp recordings demonstrated that inactivating IL neurons during REM sleep depresses their excitability. Together, our findings suggest that REM sleep after fear conditioning facilitates fear extinction by enhancing IL excitability and highlight the importance of REM sleep in the aftermath of traumatic events for protecting against traumatic memories.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-05-08)
- 국외 연구진
- 생명과학 > 신경생물학
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