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ACS Nano, May 05 2024, | https://doi.org/10.1021/acsnano.4c02171 Next-Generation Cardiac Interfacing Technologies Using Nanomaterial-Based Soft Bioelectronics

Sang Ihn Han^1,2,3,7, Sung-Hyuk Sunwoo^2,3,4,7, Chan Soon Park^5,7, Seung-Pyo Lee^2,5,6⁎, Taeghwan Hyeon^2,3⁎, and Dae-Hyeong Kim^2,3⁎

¹Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

²Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea.

³School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.

⁴Department of Chemical Engineering, Kumoh National Institute of Technology, Gumi 39177, Republic of Korea

⁵Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.

⁶Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

⁷These authors contributed equally.

^⁎Corresponding Authors : Seung-Pyo Lee, Taeghwan Hyeon, Dae-Hyeong Kim

Abstract

Cardiac interfacing devices are essential components for the management of cardiovascular diseases, particularly in terms of electrophysiological monitoring and implementation of therapies. However, conventional cardiac devices are typically composed of rigid and bulky materials and thus pose significant challenges for effective long-term interfacing with the curvilinear surface of a dynamically beating heart. In this regard, the recent development of intrinsically soft bioelectronic devices using nanocomposites, which are fabricated by blending conductive nanofillers in polymeric and elastomeric matrices, has shown great promise. The intrinsically soft bioelectronics not only endure the dynamic beating motion of the heart and maintain stable performance but also enable conformal, reliable, and large-area interfacing with the target cardiac tissue, allowing for high-quality electrophysiological mapping, feedback electrical stimulations, and even mechanical assistance. Here, we explore next-generation cardiac interfacing strategies based on soft bioelectronic devices that utilize elastic conductive nanocomposites. We first discuss the conventional cardiac devices used to manage cardiovascular diseases and explain their undesired limitations. Then, we introduce intrinsically soft polymeric materials and mechanical restraint devices utilizing soft polymeric materials. After the discussion of the fabrication and functionalization of conductive nanomaterials, the introduction of intrinsically soft bioelectronics using nanocomposites and their application to cardiac monitoring and feedback therapy follow. Finally, comments on the future prospects of soft bioelectronics for cardiac interfacing technologies are discussed.

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형식Review Paper
게재일2024년 05월 (BRIC 등록일 2024-05-07)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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