한빛사논문
- 조회117
University of Alberta
Ki-Yong An 1, Fernanda Z. Arthuso 1, Myriam Filion 1, Spencer J. Allen 1, Stephanie M. Ntoukas 1, Gordon J. Bell 1, Jessica McNeil 2, Qinggang Wang 3, Margaret L. McNeely 4, Jeff K. Vallance 5, Lin Yang 3,6, S. Nicole Culos-Reed 6,7, Leanne Dickau 3, John R. Mackey 8, Christine M. Friedenreich 3,6, Kerry S. Courneya 1
1Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton, Alberta T6G 2H9, Canada
2Department of Kinesiology, School of Health and Human Sciences, University of North Carolina at Greensboro, North Carolina 27412, USA
3Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, Alberta T2S 3C3, Canada
4Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta T6G 2H9, Canada
5Faculty of Health Disciplines, Athabasca University, Athabasca, Alberta T9S 3A3, Canada
6Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
7Faculty of Kinesiology, University of Calgary, Calgary, Alberta T2N 1N4, Canada
8Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2H9, Canada
Corresponding author : Kerry S. Courneya
Abstract
Background: Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life, treatment outcomes, and survival. Preventing and managing breast cancer-related symptoms soon after diagnosis is essential. The purpose of this study was to investigate the associations between health-related fitness (HRF) and patient-reported symptoms in newly diagnosed breast cancer patients.
Methods: This study utilized baseline data from the Alberta Moving Beyond Breast Cancer (AMBER) Cohort Study that were collected within 90 days of diagnosis. HRF measures included peak cardiopulmonary fitness (VO2peak), maximal muscular strength and endurance, flexibility, and body composition. Symptom measures included depression, sleep quality, and fatigue. Adjusted multivariable logistic regression was performed for analyses.
Results: Of 1458 participants, 51.5% reported poor sleep quality, 26.5% reported significant fatigue, and 10.4% reported moderate depression. In multivariable-adjusted models, lower relative VO2peak was independently associated with a greater likelihood of all symptom measures, including moderate depression (p < 0.001), poor sleep quality (p = 0.009), significant fatigue (p = 0.008), any symptom (p < 0.001), and multiple symptoms (p < 0.001). VO2peak demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest quartile. The strength of the threshold associations varied by the symptom measure with odds ratios ranging from ∼1.5 for poor sleep quality to ∼3.0 for moderate depression and multiple symptoms. Moreover, lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner (p = 0.001), and higher body weight was independently associated with poor sleep quality in an inverted-U pattern (p = 0.021).
Conclusion: Relative VO2peak appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diagnosed breast cancer patients. Other HRF parameters may also be important for specific symptoms. Exercise interventions targeting different HRF components may help newly diagnosed breast cancer patients manage specific symptoms and improve outcomes.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-05-07)
- 국외 연구진
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