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ACS Nano, May 02 2024, | https://doi.org/10.1021/acsnano.4c00396 Postoperative Long-Term Monitoring of Mechanical Characteristics in Reconstructed Soft Tissues Using Biocompatible, Immune-Tolerant, and Wireless Electronic Sutures

Mugeun Lee^1†, Yeontaek Lee^2†, Ji Hye Choi^3,4†, Hwajoong Kim¹, Daun Jeong^3,4, Kijun Park², Jinho Kim¹, Jae Park², Woo Young Jang^3,4*, Jungmok Seo^2*, and Jaehong Lee^1*

¹Department of Robotics and Mechatronics Engineering, DGIST Daegu 42988, Republic of Korea

²School of Electrical and Electronic Engineering, Yonsei University Seoul 03722, Republic of Korea

³Department of Orthopedic Surgery, Korea University College of Medicine Seoul 02841, Republic of Korea

⁴Institute of Nanobiomarker-Based Medicine, Korea University Seoul 02841, Republic of Korea

^†These authors are equally contributed.

^*Corresponding Authors : Woo Young Jang, Jungmok Seo, Jaehong Lee

Abstract

Accurate postoperative assessment of varying mechanical properties is crucial for customizing patient-specific treatments and optimizing rehabilitation strategies following Achilles tendon (AT) rupture and reconstruction surgery. This study introduces a wireless, chip-less, and immune-tolerant in vivo strain-sensing suture designed to continuously monitor mechanical stiffness variations in the reconstructed AT throughout the healing process. This innovative sensing suture integrates a standard medical suturing thread with a wireless fiber strain-sensing system, which incorporates a fiber strain sensor and a double-layered inductive coil for wireless readout. The winding design of Au nanoparticle-based fiber electrodes and a hollow core contribute to the fiber strain sensor's high sensitivity (factor of 6.2 and 15.1 pF for revised sensitivity), negligible hysteresis, and durability over 10,000 stretching cycles. To ensure biocompatibility and immune tolerance during extended in vivo periods, an antibiofouling lubricant layer was applied to the sensing suture. Using this sensing system, we successfully monitored the strain responses of the reconstructed AT in an in vivo porcine model. This facilitated the postoperative assessment of mechanical stiffness variations through a well-established analytical model during the healing period.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-05-03)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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