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J. Am. Chem. Soc., May 01 2024, | https://doi.org/10.1021/jacs.4c03513
Nucleic Acid-Binding Dyes as Versatile Photocatalysts for Atom-Transfer Radical Polymerization
Jaepil Jeong 1,2, Xiaolei Hu 1, Rongguan Yin 1, Marco Fantin 3, Subha R. Das 1,2, Krzysztof Matyjaszewski 1
1Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
2Center for Nucleic Acids Science & Technology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
3Department of Chemical Sciences, University of Padova, Via Marzolo 1, Padova 35131, Italy.
Corresponding Authors : Marco Fantin, Subha R. Das, Krzysztof Matyjaszewski
Abstract
Nucleic acid-binding dyes (
NuABDs) are fluorogenic probes that light up after binding to nucleic acids. Taking advantage of their fluorogenicity,
NuABDs have been widely utilized in the fields of nanotechnology and biotechnology for diagnostic and analytical applications. We demonstrate the potential of
NuABDs together with an appropriate nucleic acid scaffold as an intriguing photocatalyst for precisely controlled atom-transfer radical polymerization (ATRP). Additionally, we systematically investigated the thermodynamic and electrochemical properties of the dyes, providing insights into the mechanism that drives the photopolymerization. The versatility of the
NuABD-based platform was also demonstrated through successful polymerizations using several
NuABDs in conjunction with diverse nucleic acid scaffolds, such as G-quadruplex DNA or DNA nanoflowers. This study not only extends the horizons of controlled photopolymerization but also broadens opportunities for nucleic acid-based materials and technologies, including nucleic acid-polymer biohybrids and stimuli-responsive ATRP platforms.
논문정보
- Research article
- 2024년 05월 (BRIC 등록일 2024-05-03)
- 국외 연구진
- 바이오·의료융합 > 바이오·의료융합 기타
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