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Nano Converg., Apr 30 2024, 11 (1) | https://doi.org/10.1186/s40580-024-00423-8 Delivery-mediated exosomal therapeutics in ischemia-reperfusion injury: advances, mechanisms, and future directions

Shengzhe Ding^1†, Yu‑Jin Kim^2†, Kai‑Yu Huang^1†, Daniel Um^3†, Youngmee Jung^2,5 and Hyunjoon Kong^1,3,4,6,7*

¹Chemical & Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA

²Center for Biomaterials, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

³Bioengineering, University of Illinois, Urbana, IL 61801, USA

⁴Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801, USA

⁵Department of Electrical and Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul 03722, Republic of Korea

⁶Chan Zuckerberg Biohub-Chicago, Chicago, USA

⁷KU‑KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea

^†Shengzhe Ding, Yu-Jin Kim, Kai-yu Huang, and Daniel Um are the co-frst authors.

^*Correspondence: Hyunjoon Kong

Abstract

Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems, including the heart, brain, and kidneys. Exosomes have shown great potentials and applications in mitigating IRI-induced cell and tissue damage through modulating inflammatory responses, enhancing angiogenesis, and promoting tissue repair. Despite these advances, a more systematic understanding of exosomes from different sources and their biotransport is critical for optimizing therapeutic efficacy and accelerating the clinical adoption of exosomes for IRI therapies. Therefore, this review article overviews the administration routes of exosomes from different sources, such as mesenchymal stem cells and other somatic cells, in the context of IRI treatment. Furthermore, this article covers how the delivered exosomes modulate molecular pathways of recipient cells, aiding in the prevention of cell death and the promotions of regeneration in IRI models. In the end, this article discusses the ongoing research efforts and propose future research directions of exosome-based therapies.

논문정보

형식Review Paper
게재일2024년 04월 (BRIC 등록일 2024-05-02)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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