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Exp. Mol. Med., May 01 2024, | https://doi.org/10.1038/s12276-024-01224-z
RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
Yoona Seo1,2, Jiho Rhim1,2 and Jong Heon Kim1,2*
1Cancer Molecular Biology Branch, Research Institute, National Cancer Center, Goyang 10408, Korea.
2Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea.
*Corresponding author : Jong Heon Kim.
Abstract
Recent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression. The molecular mechanistic interplay between miRNAs and their regulatory factors, RNA-binding proteins (RBPs) and exoribonucleases, has been revealed to play a critical role in tumorigenesis. Moreover, recent studies have shown that the proliferation of hepatocellular carcinoma (HCC)-causing hepatitis C virus (HCV) is also characterized by close crosstalk of a multitude of host RBPs and exoribonucleases with miR-122 and its RNA genome, suggesting the importance of the mechanistic interplay among these factors during the proliferation of HCV. This review primarily aims to comprehensively describe the well-established roles and discuss the recently discovered understanding of miRNA regulators, RBPs and exoribonucleases, in relation to various cancers and the proliferation of a representative cancer-causing RNA virus, HCV. These have also opened the door to the emerging potential for treating cancers as well as HCV infection by targeting miRNAs or their respective cellular modulators.
논문정보
- Review Paper
- 2024년 05월 (BRIC 등록일 2024-05-02)
- 국내 연구진
- 생명과학 > 분자생물학
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