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조은지Eunji Cho

한국뇌연구원

CV File 226 kb

Exp. Mol. Med., May 01 2024, | https://doi.org/10.1038/s12276-024-01218-x Paradigm shift required for translational research on the brain

Jong Hyuk Yoon^1,9, Dongha Lee^2,9, Chany Lee^2,9, Eunji Cho^1,9, Seulah Lee¹, Amaury Cazenave-Gassiot^3,4, Kipom Kim⁵, Sehyun Chae⁶, Edward A. Dennis⁷ and Pann-Ghill Suh⁸

¹Neurodegenerative Diseases Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.

²Cognitive Science Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.

³Department of Biochemistry and Precision Medicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.

⁴Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore.

⁵Research Strategy Office, Korea Brain Research Institute, Daegu 41062, Republic of Korea.

⁶Neurovascular Unit Research Group, Korean Brain Research Institute, Daegu 41062, Republic of Korea.

⁷Department of Pharmacology and Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0601, USA.

⁸Korea Brain Research Institute, Daegu 41062, Republic of Korea.

⁹These authors contributed equally: Jong Hyuk Yoon, Dongha Lee, Chany Lee, Eunji Cho.

Corresponding author : Correspondence to Jong Hyuk Yoon.

Abstract

Biomedical research on the brain has led to many discoveries and developments, such as understanding human consciousness and the mind and overcoming brain diseases. However, historical biomedical research on the brain has unique characteristics that differ from those of conventional biomedical research. For example, there are different scientific interpretations due to the high complexity of the brain and insufficient intercommunication between researchers of different disciplines owing to the limited conceptual and technical overlap of distinct backgrounds. Therefore, the development of biomedical research on the brain has been slower than that in other areas. Brain biomedical research has recently undergone a paradigm shift, and conducting patient-centered, large-scale brain biomedical research has become possible using emerging high-throughput analysis tools. Neuroimaging, multiomics, and artificial intelligence technology are the main drivers of this new approach, foreshadowing dramatic advances in translational research. In addition, emerging interdisciplinary cooperative studies provide insights into how unresolved questions in biomedicine can be addressed. This review presents the in-depth aspects of conventional biomedical research and discusses the future of biomedical research on the brain.

논문정보

형식Review Paper
게재일2024년 05월 (BRIC 등록일 2024-05-02)
연구진국내(교신)+국외 연구진
분야 생명과학 > 분자생물학

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