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Exp. Mol. Med., May 01 2024, | https://doi.org/10.1038/s12276-024-01211-4
Socialized mitochondria: mitonuclear crosstalk in stress
Kyung Hwa Kim1* and Cho Bi Lee1
1Department of Health Sciences, The Graduate School of Dong-A University, 840 Hadan-dong, Saha-gu, Busan 49315, Korea.
*Corresponding author : Correspondence to Kyung Hwa Kim.
Abstract
Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling organelles that are involved in intracellular interactions with other organelles. Remarkably, stressed mitochondria appear to induce a beneficial response that restores mitochondrial function and cellular homeostasis. These mitochondrial stress-centered signaling pathways have been rapidly elucidated in multiple organisms. In this review, we examine current perspectives on how mitochondria communicate with the rest of the cell, highlighting mitochondria-to-nucleus (mitonuclear) communication under various stresses. Our understanding of mitochondria as signaling organelles may provide new insights into disease susceptibility and lifespan extension.
논문정보
- Review Paper
- 2024년 05월 (BRIC 등록일 2024-05-02)
- 국내 연구진
- 생명과학 > 세포생물학
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