한빛사논문
- 조회372
Jingxia Lv a,1, Renye Yue a,b,1, Huiyi Liu a,1, Huan Du a, Chang Lu a, Cheng Zhang a, Guoqiang Guan a, Sunhong Min c, Shuangyan Huan a, Heemin Kang c,d, Guosheng Song a
aState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China
bSchool of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR China
cDepartment of Materials Science and Engineering, Korea University, Seoul 02841, Republic of Korea
dCollege of Medicine, Korea University, Seoul 02841, Republic of Korea
1These authors contribute equally.
Corresponding authors: Shuangyan Huan, Heemin Kang, Guosheng Song
Abstract
Enzymes are key components of the biological microenvironment, possessing outstanding catalytic properties and exceptional biorecognition capabilities. Abnormal expression or activity of the enzyme is associated with many disease-associated micro-environments and aberrant cell processes. Therefore, dynamic imaging for enzyme activity is tremendously meaningful for disease diagnosis and treatment. Magnetic resonance imaging (MRI) is a reliable imaging technology for disease diagnosis with the merits of high resolution, non-invasive, and sufficient penetration depth. To monitor enzyme activity, various enzyme-activated MRI probes were developed, which possess a weak background signal and high-sensitivity enzyme imaging for tumors in vivo. Furthermore, certain probes can realize both diagnosis and treatment of cancer as well as other ailments. This leads to a more efficient and secure therapeutic approach guided by imaging techniques. And the therapeutic methods of enzyme-sensitive MRI probes primarily encompass phototherapy, photodynamic therapy, chemodynamic therapy, chemotherapy, radiotherapy, as well as combination therapy. In this review, we systematically introduced the types and mechanisms of enzyme-activated probes and further summarized their application on disease diagnosis and therapy. Finally, we also prospected the development tendency of enzyme-responsive MRI probes.
논문정보
- Review Paper
- 2024년 04월 (BRIC 등록일 2024-04-30)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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