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Biomater. Res., 25 Apr 2024 Vol 28, Article ID: 0026 | https://doi.org/10.34133/bmr.0026 Targeting Heme Oxygenase 2 (HO2) with TiNIR, a Theragnostic Approach for Managing Metastatic Non-Small Cell Lung Cancer

Seul-Ki Mun^1,2†, Hyun Bo Sim^1†, Jae-Hyuk Lee^3†, Hyeongyeong Kim¹, Dae-Han Park¹, Yong-An Lee⁴, Ji Yeon Han¹, Yu-Jeong Choi¹, Jun Sang Son¹, Jeongwon Park³, Tae-Hwan Lim², Sung-Tae Yee², Young-Tae Chang^5,6, Seongsoo Lee^3,7,8*, Dong-Jo Chang^2*, and Jong-Jin Kim^1*

¹Department of Biomedical Science, Sunchon National University, Suncheon 57922, Republic of Korea.

²College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.

³Gwangju Center, Korea Basic Science Institute (KBSI), Gwangju 61751, Republic of Korea.

⁴Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, Singapore 138672, Republic of Singapore.

⁵School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.

⁶Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.

⁷Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea.

⁸Department of Bio-Analysis Science, University of Science & Technology, Daejeon 34113, Republic of Korea.

^*Address correspondence to S.L.; D.-J.C.; J.-J.K.

^†These authors contributed equally to this work

Abstract

Despite notable advancements in cancer therapeutics, metastasis remains a primary obstacle impeding a successful prognosis. Our prior study has identified heme oxygenase 2 (HO2) as a promising therapeutic biomarker for the aggressive subsets within tumor. This study aims to systematically evaluate HO2 as a therapeutic target of cancer, with a specific emphasis on its efficacy in addressing cancer metastasis. Through targeted inhibition of HO2 by TiNIR (tumor-initiating cell probe with near infrared), we observed a marked increase in reactive oxygen species. This, in turn, orchestrated the modulation of AKT and cJUN activation, culminating in a substantial attenuation of both proliferation and migration within a metastatic cancer cell model. Furthermore, in a mouse model, clear inhibition of cancer metastasis was unequivocally demonstrated with an HO2 inhibitor administration. These findings underscore the therapeutic promise of targeting HO2 as a strategic intervention to impede cancer metastasis, enhancing the effectiveness of cancer treatments.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-29)
연구진국내(교신)+국외 연구진
분야 생명과학 > 생명과학 기타

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