한빛사논문
- 조회766
Garima Sharma 1,2,13, Amit Sharma 1,3,13, Inhae Kim 2, Dong Gon Cha 1,4, Somi Kim 1, Eun Seo Park 1,4, Jae Gyun Noh 1, Juhee Lee 5, Ja Hyeon Ku 6, Yoon Ha Choi 1,4, JungHo Kong 1, Haena Lee 1, Haeun Ko 1, Juhun Lee 2, Anna Notaro 7, Seol Hee Hong 8, Joon Haeng Rhee 8, Sang Geon Kim 9, Cristina De Castro 7, Antonio Molinaro 7, Kunyoo Shin 5,10, Sanguk Kim 1, Jong Kyoung Kim 1,4, Dipayan Rudra 2,11,* & Sin-Hyeog Im 1,2,12,*
1Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
2ImmunoBiome, Bio Open Innovation Center, Pohang, Republic of Korea.
3Innovation Research Center for Bio-future Technology (B-IRC), Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
4Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
5Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Republic of Korea.
6Department of Urology, College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
7Department of Chemical Sciences, University of Napoli Federico II Complesso Universitario Monte Santangelo, Via Cintia 4, I-80126, Naples, Italy.
8Clinical Vaccine R&D Center and Combinatorial Tumor Immunotherapy MRC, Chonnam National University, Hwasun-gun, Republic of Korea.
9College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul, Republic of Korea.
10Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
11School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
12Institute for Convergence Research and Education in Advanced Technology, Yonsei University, Seoul, Republic of Korea.
13These authors contributed equally: Garima Sharma, Amit Sharma.
*Corresponding authors: correspondence to Dipayan Rudra or Sin-Hyeog Im
Abstract
Innate immune cells generate a multifaceted antitumor immune response, including the conservation of essential nutrients such as iron. These cells can be modulated by commensal bacteria; however, identifying and understanding how this occurs is a challenge. Here we show that the food commensal Lactiplantibacillus plantarum IMB19 augments antitumor immunity in syngeneic and xenograft mouse tumor models. Its capsular heteropolysaccharide is the major effector molecule, functioning as a ligand for TLR2. In a two-pronged manner, it skews tumor-associated macrophages to a classically active phenotype, leading to generation of a sustained CD8+ T cell response, and triggers macrophage ‘nutritional immunity’ to deploy the high-affinity iron transporter lipocalin-2 for capturing and sequestering iron in the tumor microenvironment. This process induces a cycle of tumor cell death, epitope expansion and subsequent tumor clearance. Together these data indicate that food commensals might be identified and developed into ‘oncobiotics’ for a multi-layered approach to cancer therapy.
논문정보
- Research article
- 2024년 04월 (BRIC 등록일 2024-04-26)
- 국내(교신)+국외 연구진
- 생명과학 > 면역학
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