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Exp. Mol. Med., Apr 25 2024, | https://doi.org/10.1038/s12276-024-01233-y
Enhancer-promoter specificity in gene transcription: molecular mechanisms and disease associations
Meyer J. Friedman1, Tobias Wagner1, Haram Lee2, Michael G. Rosenfeld1 and Soohwan Oh2
1Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.
2College of Pharmacy Korea University, 2511 Sejong-ro, Sejong 30019, Republic of Korea.
Corresponding authors : Correspondence to Michael G. Rosenfeld or Soohwan Oh.
Abstract
Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial transcriptional specificity in metazoans. Since the discovery of the first enhancer element in simian virus 40, there has been substantial interest in unraveling the mechanism(s) by which enhancers communicate with their partner promoters to ensure proper gene expression. These research efforts have benefited considerably from the application of increasingly sophisticated sequencing- and imaging-based approaches in conjunction with innovative (epi)genome-editing technologies; however, despite various proposed models, the principles of enhancer-promoter interaction have still not been fully elucidated. In this review, we provide an overview of recent progress in the eukaryotic gene transcription field pertaining to enhancer-promoter specificity. A better understanding of the mechanistic basis of lineage- and context-dependent enhancer-promoter engagement, along with the continued identification of functional enhancers, will provide key insights into the spatiotemporal control of gene expression that can reveal therapeutic opportunities for a range of enhancer-related diseases.
논문정보
- Review Paper
- 2024년 04월 (BRIC 등록일 2024-04-26)
- 국내(교신)+국외 연구진
- 생명과학 > 유전자발현
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