한빛사
>
한빛사논문
한빛사논문
- 조회507
Exp. Mol. Med., Apr 25 2024, | https://doi.org/10.1038/s12276-024-01207-0
Viral remodeling of the 4D nucleome
Kyoung-Dong Kim1 and Paul M. Lieberman2
1Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
2The Wistar Institute, Philadelphia, PA 19104, USA.
Corresponding authors : Correspondence to Kyoung-Dong Kim or Paul M. Lieberman.
Abstract
The dynamic spatial organization of genomes across time, referred to as the four-dimensional nucleome (4DN), is a key component of gene regulation and biological fate. Viral infections can lead to a reconfiguration of viral and host genomes, impacting gene expression, replication, latency, and oncogenic transformation. This review provides a summary of recent research employing three-dimensional genomic methods such as Hi-C, 4C, ChIA-PET, and HiChIP in virology. We review how viruses induce changes in gene loop formation between regulatory elements, modify chromatin accessibility, and trigger shifts between A and B compartments in the host genome. We highlight the central role of cellular chromatin organizing factors, such as CTCF and cohesin, that reshape the 3D structure of both viral and cellular genomes. We consider how viral episomes, viral proteins, and viral integration sites can alter the host epigenome and how host cell type and conditions determine viral epigenomes. This review consolidates current knowledge of the diverse host-viral interactions that impact the 4DN.
논문정보
- Review Paper
- 2024년 04월 (BRIC 등록일 2024-04-25)
- 국내(교신)+국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
