한빛사논문
- 조회352
University of California, 울산과학기술원(UNIST)
Youngbin Tchoe 1 2 †, Tianhai Wu 1 †, Hoi Sang U 1, David M Roth 1 3, Dongwoo Kim 1, Jihwan Lee 1, Daniel R Cleary 1 4 5, Patricia Pizarro 1 6, Karen J Tonsfeldt 1 7, Keundong Lee 1, Po Chun Chen 1, Andrew M Bourhis 1, Ian Galton 8, Brian Coughlin 9 10, Jimmy C Yang 11 12, Angelique C Paulk 9 10, Eric Halgren 5, Sydney S Cash 9 10, Shadi A Dayeh 1 13 *
1Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
2Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea.
3Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.
4Center for the Future of Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
5Department of Neurological Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
6Department of Neurological Surgery, Oregon Health & Science University, Mail code CH8N, 3303 SW Bond Avenue, Portland, OR 97239, USA.
7Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
8Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
9Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114, USA.
10Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
11Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
12Department of Neurological Surgery, Ohio State University, Columbus, OH 43210, USA.
13Departments of Radiology and Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
†These authors contributed equally
*Corresponding authors: correspondence to Shadi A Dayeh
Abstract
Functional mapping during brain surgery is applied to define brain areas that control critical functions and cannot be removed. Currently, these procedures rely on verbal interactions between the neurosurgeon and electrophysiologist, which can be time-consuming. In addition, the electrode grids that are used to measure brain activity and to identify the boundaries of pathological versus functional brain regions have low resolution and limited conformity to the brain surface. Here, we present the development of an intracranial electroencephalogram (iEEG)–microdisplay that consists of freestanding arrays of 2048 GaN light-emitting diodes laminated on the back of micro-electrocorticography electrode grids. With a series of proof-of-concept experiments in rats and pigs, we demonstrate that these iEEG-microdisplays allowed us to perform real-time iEEG recordings and display cortical activities by spatially corresponding light patterns on the surface of the brain in the surgical field. Furthermore, iEEG-microdisplays allowed us to identify and display cortical landmarks and pathological activities from rat and pig models. Using a dual-color iEEG-microdisplay, we demonstrated coregistration of the functional cortical boundaries with one color and displayed the evolution of electrical potentials associated with epileptiform activity with another color. The iEEG-microdisplay holds promise to facilitate monitoring of pathological brain activity in clinical settings.
논문정보
- Research article
- 2024년 04월 (BRIC 등록일 2024-06-12)
- 국내+국외 연구진
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