한빛사논문
Leslie Jaesun Ha,1,15 Hyeon-Gu Yeo,2,3,15 Yu Gyeong Kim,2,3,15 Inhyeok Baek,1,15 Eunha Baeg,12,13,15 Young Hee Lee,1 Jinyoung Won,2 Yunkyo Jung,1,2 Junghyung Park,2 Chang-Yeop Jeon,2 Keonwoo Kim,2,5 Jisun Min,1,2 Youngkyu Song,6 Jeong-Heon Park,6 Kyung Rok Nam,7 Sangkyu Son,9,10,11 Seng Bum Michael Yoo,9,10,11 Sung-hyun Park,2 Won Seok Choi,2 Kyung Seob Lim,4 Jae Yong Choi,7,8,* Jee-Hyun Cho,6,* Youngjeon Lee,2,3,* and Hyung Jin Choi 1,14,16,*
1Department of Biomedical Sciences, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea
2National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea
3KRIBB School of Bioscience, Korea National University of Science and Technology, Daejeon, Republic of Korea
4Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea
5School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea
6Center for Bio-imaging and Translational Research, Korea Basic Science Institute, Cheongju, Republic of Korea
7Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
8Radiological and Medico-Oncological Sciences, Korea National University of Science and, Technology, Seoul, Republic of Korea
9Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea
10Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea
11Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea
12Department of Nano-bioengineering, Incheon National University, Incheon, Republic of Korea
13Center for Brain-Machine Interface, Incheon National University, Incheon, Republic of Korea
14Department of Brain and Cognitive Sciences, Seoul National University, Seoul, South Korea
15These authors contributed equally
16Lead contact
*Corresponding authors: correspondence to Jae Yong Choi, Jee-Hyun Cho, Youngjeon Lee or Hyung Jin Choi
Abstract
Maladaptive feeding behavior is the primary cause of modern obesity. While the causal influence of the lateral hypothalamic area (LHA) on eating behavior has been established in rodents, there is currently no primate-based evidence available on naturalistic eating behaviors. We investigated the role of LHA GABAergic (LHAGABA) neurons in eating using chemogenetics in three macaques. LHAGABA neuron activation significantly increased naturalistic goal-directed behaviors and food motivation, predominantly for palatable food. Positron emission tomography and magnetic resonance spectroscopy validated chemogenetic activation. Resting-state functional magnetic resonance imaging revealed that the functional connectivity (FC) between the LHA and frontal areas was increased, while the FC between the frontal cortices was decreased after LHAGABA neuron activation. Thus, our study elucidates the role of LHAGABA neurons in eating and obesity therapeutics for primates and humans.
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