최명철 (KAIST)

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KAIST

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J. Am. Chem. Soc., Apr 23 2024, | https://doi.org/10.1021/jacs.4c00544 Water Hydrogen-Bond Mediated Layer by Layer Alignment of Lipid Rafts as a Precursor of Intermembrane Processes

Suho Lee,^†,§Ji Hyun Bak^,‡,§ Yuno Lee,^‡,∥ Dae-Woong Jeong,^†,⊥ Jaehee Lee,^† KeunMin Ken Lee,^† Hasaeam Cho,^† Hyun Hwi Lee,^¶ Changbong Hyeon,^∗,‡ and Myung Chul Choi^∗,†

^†Department of Bio and Brain Engineering, KAIST, Daejeon, 34141, Korea

^‡School of Computational Science, Korea Institute for Advanced Study, Seoul, 02455, Korea

^¶Pohang Accelerator Lab, POSTECH, Pohang, 37673, Korea

^§These authors contributed equally to this work.

^∥Current address: Drug Information Research Center, Korea Research Institute of Chemical Technology, Daejeon, 34114, Korea

^⊥Current address: LG AI Research, Seoul, 07789, Korea

S.L. and J.H.B. contributed equally to this work.

Corresponding Authors : Changbong Hyeon, Myung Chul Choi

Abstract

Lipid rafts, which are dynamic nanodomains in the plasma membrane, play a crucial role in intermembrane processes by clustering together and growing in size within the plane of the membrane while also aligning with each other across different membranes. However, the physical origin of layer by layer alignment of lipid rafts remains to be elucidated. Here, by using fluorescence imaging and synchrotron X-ray reflectivity in a phase-separated multilayer system, we find that the alignment of raft-mimicking L _o domains is regulated by the distance between bilayers. Molecular dynamics simulations reveal that the aligned state is energetically preferred when the intermembrane distance is small due to its ability to minimize the volume of surface water, which has fewer water hydrogen bonds (HBs) compared to bulk water. Our results suggest that water HB-driven alignment of lipid rafts plays a role as a precursor of intermembrane processes such as cell-cell fusion, virus entry, and signaling.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-24)
연구진국내 연구진
분야 생명과학 > 구조생물 및 생물물리학

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