이정환 (단국대학교 조직재생공학연구원/치과대학/나노바이오의과학과)

한빛사논문

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단국대학교 조직재생공학연구원/치과대학/나노바이오의과학과

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Adv. Healthc. Mater., Apr 22 2024, | https://doi.org/10.1002/adhm.202400154 Strontium/Silicon/Calcium-Releasing Hierarchically Structured 3D-Printed Scaffolds Accelerate Osteochondral Defect Repair

Cheng Ji Li ^1,2, Jeong-Hui Park ¹, Gang Shi Jin ¹, Nandin Mandakhbayar¹, Donghyeon Yeo ^1,2, Jun Hee Lee ^1,2,3,4,5,6, Jung-Hwan Lee^1,2,3,5,6, Hye Sung Kim ^1,2,3,5, Hae-Won Kim ^1,2,3,4,5,6

¹Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea.

²Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 31116, Republic of Korea.

³Dankook Physician Scientist Research Center, Dankook University Hospital, Cheonan, 31116, Republic of Korea.

⁴Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, 31116, Republic of Korea.

⁵Mechanobiology Dental Medicine Research Center, Dankook University, Cheonan, Chungcheognam-do, 31116, Republic of Korea.

⁶Cell & Matter Institute, Dankook University, Cheonan, 31116, Republic of Korea.

CORRESPONDING AUTHORS : Jung-Hwan Lee, Hye Sung Kim, Hae-Won Kim

Abstract

Articular cartilage defects are a global challenge, causing substantial disability. Repairing large defects is problematic, often exceeding cartilage's self-healing capacity and damaging bone structures. To tackle this problem, we develop a scaffold-mediated therapeutic ion delivery system. These scaffolds are constructed from poly(ε-caprolactone) and strontium (Sr)-doped bioactive nanoglasses (SrBGn), creating a unique hierarchical structure featuring macro-pores from 3D printing, micro-pores, and nano-topologies due to SrBGn integration. The SrBGn-embedded scaffolds (SrBGn-μCh) release Sr, silicon (Si), and calcium (Ca) ions, which improve chondrocyte activation, adhesion, proliferation, and maturation-related gene expression. This multiple ion delivery significantly affects metabolic activity and maturation of chondrocytes. Importantly, Sr ions may play a role in chondrocyte regulation through the Notch signaling pathway. Notably, the scaffold's structure and topological cues expedite the recruitment, adhesion, spreading, and proliferation of chondrocytes and bone marrow-derived mesenchymal stem cells. Si and Ca ions accelerate osteogenic differentiation and blood vessel formation, while Sr ions enhance the polarization of M2 macrophages. Our findings show that SrBGn-μCh scaffolds accelerate osteochondral defect repair by delivering multiple ions and providing structural/topological cues, ultimately supporting host cell functions and defect healing. This scaffold holds great promise for osteochondral repair applications. This article is protected by copyright. All rights reserved.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-23)
연구진국내 연구진
분야 의약학 > 재생의학

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