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Eur. Resp. J., Apr 18 2024, 2301037 | https://doi.org/10.1183/13993003.01037-2023 The association of blood eosinophil counts and FEV1 decline: a cohort study

Yun Soo Hong^1,2,9, Hye Yun Park^3,9, Seungho Ryu^4,5,6, Sun Hye Shin³, Di Zhao², Dave Singh⁷, Eliseo Guallar², Juhee Cho^2,6, Yoosoo Chang^4,5,6,10⇑and Seong Yong Lim^8,10

¹McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

²Departments of Epidemiology and Medicine, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA

³Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

⁴Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, gSungkyunkwan University School of Medicine, Seoul, South Korea

⁵Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea

⁶Department of Clinical Research and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, South Korea

⁷Medicines Evaluation Unit, University of Manchester, Manchester University NHS Foundation Trust, Manchester, UK

⁸Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea

⁹Drs. Yun Soo Hong and Hye Yun Park contributed equally as co-first authors

¹⁰Drs. Yoosoo Chang and Seong Yong Lim contributed equally as co-corresponding authors

Corresponding authors: Yoosoo Chang; Seong Yong Lim

Abstract

Accelerated lung function decline is characteristic of chronic obstructive pulmonary disease (COPD). However, the association between blood eosinophil counts and lung function decline, accounting for current smoking status, in young individuals without prevalent lung disease is not fully understood. This is a cohort study of 629 784 Korean adults without COPD or a history of asthma at baseline who participated in health screening examinations including spirometry and differential white blood cell counts. We used linear mixed effects model to estimate the annual change in FEV ₁ (mL) by baseline blood eosinophil count, adjusting for covariates including smoking status. We also performed a stratified analysis by baseline and time-varying smoking status. During a mean follow-up of 6.5 years (maximum of 17.8 years), the annual change in FEV ₁ (95% confidence interval [CI]) in participants with eosinophil counts <100, 100-199, 200-299, 300-499, and ≥500 cells/µL in the fully adjusted model were -23.3 (-23.9, -22.7), -24.3 (-24.9, -23.7), -24.8 (-25.5, -24.2), -25.5 (-26.2, -24.8), and -26.8 (-27.7, -25.9) mL, respectively. When stratified by smoking status, participants with higher eosinophil count had a faster decline in FEV ₁ than those with lower eosinophil count in both never- and ever-smokers, which persisted when time-varying smoking status was used. Blood eosinophil counts were associated with a faster lung function decline among healthy individuals without lung disease, independent of smoking status. The findings suggest that blood eosinophil counts contribute to the risk of faster lung function decline, particularly among younger adults without a history of lung disease.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-23)
연구진국내(교신)+국외 연구진
분야 의약학 > 응용의학

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