한빛사논문
- 조회277
Nem Singh a,b,1, Miae Won a,c,1, Jusung An a,1, Changyu Yoon a, Dongeun Kim a,c, Suk Joong Lee a, Heemin Kang b, Jong Seung Kim a,c
aDepartment of Chemistry, Korea University, Seoul 02841, South Korea
bDepartment of Materials Science and Engineering, Korea University, Seoul 02841, South Korea
cTheranoChem Incorporation, Seongbuk-gu, Seoul 02856, South Korea
1These authors contributed equally to this work.
Corresponding authors: Jong Seung Kim, Heemin Kang, Suk Joong Lee
Abstract
The global prevalence of cancer presents a formidable challenge to medical systems, compelling the pursuit of novel and effective therapeutic modalities to improve patient survival rates. In this context, cancer phototherapy, encompassing both photodynamic (PDT) and photothermal (PTT) therapies, stands out as a targeted, minimally invasive modality to trigger the selective ablation of cancer cells. Covalent organic frameworks (COFs), with their distinct crystalline and porous nature, excellent biocompatibility, and chemical robustness, are increasingly recognized as outstanding materials to propel cancer phototherapy forward. In this review, we focus on examining the application of COF nanoparticles in the domain of PDT and PTT, demonstrating their potent anti-cancer capabilities. We pay special attention to combination therapies that exploit COFs, particularly those that elicit immunogenic cell death. These synergistic approaches offer considerable promise for the enhancement of cancer therapy efficiency. Additionally, we address the prevalent hurdles associated with COF-based cancer phototherapy, such as toxicity concerns, in vivo stability issues, and the complexities of photo agent delivery. We also discuss potential methods to overcome these barriers, especially through surface modifications of COFs. The review concludes by charting prospective research paths and the urgent need for the establishment of standardized procedures to fast-track the clinical adoption of COF-based phototherapy. By offering a detailed yet succinct outline of the capabilities of COFs in advancing cancer phototherapy, this article provides valuable insights for investigators in this vibrant field.
논문정보
- Review Paper
- 2024년 05월 (BRIC 등록일 2024-04-22)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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