Rachmi Luthfikasari (강원대학교) | 한빛사논문 > 한빛사

한빛사논문

조회224

Rachmi LuthfikasariRachmi Luthfikasari

강원대학교

Adv. Healthc. Mater., Apr 18 2024, | https://doi.org/10.1002/adhm.202400581 Stimuli-Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms-Macrophage Interface

Keya Ganguly^1,3⸸, Rachmi Luthfikasari^1⸸, Aayushi Randhawa^1,2, Sayan Deb Dutta¹, Tejal V. Patil^1,2, Rumi Acharya^1,2, and Ki-Taek Lim^{1,2, *}

¹Department of Biosystems Engineering, Kangwon National University, Chuncheon-24341, Republic of Korea.

²InterdisciplinaryProgram in Smart Agriculture, KangwonNational University, Chuncheon-24341, Republic of Korea.

³Institute of Forest Science, Kangwon National University, Chuncheon-24341, Republic of Korea.

^*Corresponding Author:Prof./Dr. Ki-Taek Lim

^⸸Contributed equally

Abstract

Macrophages play an essential role in immunotherapy and tissue regeneration owing to their remarkable plasticity and diverse functions. Recent bioengineering developments have focused on using external physical stimuli such as electric and magnetic fields, temperature, and compressive stress, among others, on micro/nanostructures to induce macrophage polarization, thereby increasing their therapeutic potential. However, it is difficult to find a concise review of the interaction between physical stimuli, advanced micro/nanostructures, and macrophage polarization. This review examines the present research on physical stimuli-induced macrophage polarization on micro/nanoplatforms, emphasizing the synergistic role of fabricated structure and stimulation for advanced immunotherapy and tissue regeneration. We provide a concise overview of the research advancements investigating the impact of physical stimuli-including electric fields, magnetic fields, compressive forces, fluid shear stress, photothermal stimuli, and multiple stimulations on the polarization of macrophages within complex engineered structures. The prospective implications of these strategies in regenerative medicine and immunotherapeutic approaches have been highlighted. This review will aid in creating stimuli-responsive platforms for immunomodulation and tissue regeneration. This article is protected by copyright. All rights reserved.

논문정보

형식Review Paper
게재일2024년 04월 (BRIC 등록일 2024-04-22)
연구진국내 연구진
분야 바이오·의료융합 > 의료기기

댓글 작성 로그인

CV 열람하기

연락처 보기