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Immunol. Rev., Apr 17 2024, | https://doi.org/10.1111/imr.13335
The potency of hematopoietic stem cell reprogramming for changing immune tone
Andrew W. Daman1,2, Jin Gyu Cheong1,2, Laura Berneking3, Steven Z. Josefowicz1,2
1Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, New York, USA
2Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA
3Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Andrew W. Daman and Jin Gyu Cheong contributed equally to this study.
Correspondence: Andrew W. Daman, Jin Gyu Cheong, and Steven Z. Josefowicz,
Abstract
Innate immune memory endows innate immune cells with antigen independent heightened responsiveness to subsequent challenges. The durability of this response can be mediated by inflammation induced epigenetic and metabolic reprogramming in hematopoietic stem and progenitor cells (HSPCs) that are maintained through differentiation to mature immune progeny. Understanding the mechanisms and extent of trained immunity induction by pathogens and vaccines, such as BCG, in HSPC remains a critical area of exploration with important implications for health and disease. Here we review these concepts and present new analysis to highlight how inflammatory reprogramming of HSPC can potently alter immune tone, including to enhance specific anti-tumor responses. New findings in the field pave the way for novel HSPC targeting therapeutic strategies in cancer and other contexts of immune modulation. Future studies are expected to unravel diverse and extensive effects of infections, vaccines, microbiota, and sterile inflammation on hematopoietic progenitor cells and begin to illuminate the broad spectrum of immunologic tuning that can be established through altering HSPC phenotypes. The purpose of this review is to draw attention to emerging and speculative topics in this field where we posit that focused study of HSPC in the framework of trained immunity holds significant promise.
논문정보
- Review Paper
- 2024년 04월 (BRIC 등록일 2024-04-25)
- 국외 연구진
- 생명과학 > 면역학
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