한빛사논문
- 조회390
Hye-Sun Park1, Sang Ho Park2, Yeseul Seong2, Hyo Jeong Kim3, Hoon Young Choi3, Yumie Rhee4, Hyeong Cheon Park3 & Jong Hyun Jhee3*
1Division of Endocrinology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea;
2Department ofInternal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea;
3Division of Nephrology, Department of Internal Medicine,Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea;
4Department of Internal Medicine, Endocrine Research Institute, YonseiUniversity College of Medicine, Seoul, Republic of Korea
*Correspondence to: Jong Hyun Jhee
Abstract
Background: The association between the adiponectin-to-leptin ratio (A/L ratio) and the risk of incident chronic kidney disease (CKD) is poorly understood. This study aimed to investigate the association between A/L ratio and the risk of incident CKD and to examine whether such a relationship varied according to sex and body composition.
Methods: In this prospective community-based cohort, participants with normal kidney function were analysed (N = 5192). The association between the A/L ratio at baseline and the risk of incident CKD, defined as two or more occasions with an estimated glomerular filtration rate of <60 mL/min/m2 or proteinuria of ≥1+ on a dipstick test during the follow-up period, was evaluated using multivariable Cox proportional hazards analyses. Subgroup analyses were conducted based on sex, body mass index (BMI) and the presence of sarcopenia.
Results: The participants' mean age was 57.2 ± 8.3 years, and 53.2% were women. The A/L ratio was higher in men compared with women (1.5 [0.8-3.2] and 0.5 [0.3-0.9] μg/ng, P < 0.001). During a median follow-up of 9.8 [9.5-10.0] years, 417 incident CKD events occurred (8.7 per 1000 person-years). Men in the highest quartile of A/L ratio had a lower risk of incident CKD (adjusted hazard ratio [aHR], 0.57; 95% confidence interval [CI], 0.33-0.99) than those in the lowest quartile. Additionally, a 1.0 increase in A/L ratio was associated with a 12% decreased risk of incident CKD in men (aHR, 0.88; 95% CI, 0.80-0.97). However, no significant association was observed in women. In subgroup analysis stratified by BMI and the presence of sarcopenia, the association between a high A/L ratio and a reduced risk of incident CKD was consistent in men with a BMI < 23.0 kg/m2 and those with sarcopenia. However, no significant association was observed between men with a BMI ≥ 23.0 kg/m2 and those without sarcopenia.
Conclusions: A high A/L ratio is an independent marker of a reduced risk of incident CKD in men, especially in those with a BMI < 23.0 kg/m2 and sarcopenia.
논문정보
- Research article
- 2024년 04월 (BRIC 등록일 2024-04-19)
- 국내 연구진
- 의약학 > 응용의학
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